K
Karen Hsiao
Researcher at University of California, San Francisco
Publications - 15
Citations - 3265
Karen Hsiao is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Genetically modified mouse & Transgene. The author has an hindex of 13, co-authored 15 publications receiving 3192 citations. Previous affiliations of Karen Hsiao include University of Minnesota & Johns Hopkins University.
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Journal ArticleDOI
Scrapie prion protein contains a phosphatidylinositol glycolipid
TL;DR: Observations indicate that PrPC is anchored to the cell surface by the glycolipid, which is derived from PrPSc by limited proteolysis at the amino terminus.
Journal ArticleDOI
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
Karen Hsiao,Harry F. Baker,Timothy J. Crow,Mark Poulter,Frank Owen,Joseph D. Terwilliger,David Westaway,Jurg Ott,Jurg Ott,Stanley B. Prusiner +9 more
TL;DR: It is shown here that PrP codon 102 is linked to the putative gene for the syndrome in two pedigrees, providing the best evidence to date that this familial condition is inherited despite also being infectious, and that substitution of leucine for proline at PrPcodon 102 may lead to the development of Gerstmann–Sträussler syndrome.
Journal ArticleDOI
Mutation of the Prion Protein in Libyan Jews with Creutzfeldt–Jakob Disease
Karen Hsiao,Zeev Meiner,Esther Kahana,Carin Cass,Irit Kahana,Dana Avrahami,Guglielmo Scarlato,Oded Abramsky,Stanley B. Prusiner,Ruth Gabizon +9 more
TL;DR: The codon 200 lysine mutation of the prion-protein gene is consistently present among Libyan Jews with Creutzfeldt-Jakob disease, strongly supporting a genetic pathogenesis of their illness.
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Mutant prion proteins in gerstmann-sträussler-scheinker disease with neurofibrillary tangles
Karen Hsiao,Stephen R. Dlouhy,Martin R. Farlow,Carin Cass,Maria Da Costa,P. Michael Conneally,Marion E. Hodes,Bernardino Ghetti,Stanley B. Prusiner +8 more
TL;DR: These mutations in PrP are the first to be associated with the appear ance of both PrP amyloid plaques and neocortical NFTs in GSS patients.
Journal ArticleDOI
Linkage of the Indiana kindred of gerstmann-sträussler-scheinker disease to the prion protein gene
Stephen R. Dlouhy,Karen Hsiao,Martin R. Farlow,Tatiana Foroud,P. Michael Conneally,Patricia Johnson,Stanley B. Prusiner,Marion E. Hodes,Bernardino Ghetti +8 more
TL;DR: Tight linkage of the disease-causing gene to PRNP is demonstrated and the hypothesis that the codon 198 mutation is the cause of IK-GSS is supported.