D
David Westaway
Researcher at University of California, San Francisco
Publications - 27
Citations - 7199
David Westaway is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Scrapie & Gene. The author has an hindex of 19, co-authored 27 publications receiving 7063 citations. Previous affiliations of David Westaway include University of California, Berkeley.
Papers
More filters
Journal ArticleDOI
A cellular gene encodes scrapie PrP 27-30 protein
Bruno Oesch,Bruno Oesch,David Westaway,Monika Wälchli,Monika Wälchli,Michael P. McKinley,Stephen B. H. Kent,Stephen B. H. Kent,Ruedi Aebersold,Ruedi Aebersold,Ronald A. Barry,Paul Tempst,Paul Tempst,David B. Teplow,David B. Teplow,Leroy Hood,Leroy Hood,Stanley B. Prusiner,Stanley B. Prusiner,Charles Weissmann,Charles Weissmann +20 more
TL;DR: A clone encoding PrP 27-30, the major protein in purified preparations of scrapie agent, was selected from a scrapie-infected hamster brain cDNA library by oligonucleotide probes corresponding to the N terminus of the protein.
Journal ArticleDOI
Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication.
Stanley B. Prusiner,Michael R. Scott,Dallas Foster,Keh-Ming Pan,Darlene Groth,Carol Mirenda,Marilyn Torchia,Shu-Lian Yang,Dan Serban,George A. Carlson,Peter Hoppe,David Westaway,Stephen J. DeArmond +12 more
TL;DR: The results argue that species specificity of scrapie prions resides in the PrP sequence and prion synthesis is initiated by a species-specific interaction between PrPSc in the inoculum and homologous PrPC.
Journal ArticleDOI
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
Karen Hsiao,Harry F. Baker,Timothy J. Crow,Mark Poulter,Frank Owen,Joseph D. Terwilliger,David Westaway,Jurg Ott,Jurg Ott,Stanley B. Prusiner +9 more
TL;DR: It is shown here that PrP codon 102 is linked to the putative gene for the syndrome in two pedigrees, providing the best evidence to date that this familial condition is inherited despite also being infectious, and that substitution of leucine for proline at PrPcodon 102 may lead to the development of Gerstmann–Sträussler syndrome.
Journal ArticleDOI
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene
Konrad Basler,Bruno Oesch,Michael R. Scott,David Westaway,Monika Wälchli,Darlene Groth,Michael P. McKinley,Stanley B. Prusiner,Charles Weissmann +8 more
TL;DR: The primary structure of PrP encoded by the gene of a healthy animal does not differ from that encoded by a cDNA from a scrapie-infected animal, suggesting that the different properties ofPrP from normal and scrapie -infected brains are due to post-translational events.
Journal ArticleDOI
Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques
Michael R. Scott,Dallas Foster,Carol Mirenda,Dan Serban,Frank Coufal,Monika Wälchli,Marilyn Torchia,Darlene Groth,George A. Carlson,Stephen J. DeArmond,David Westaway,Stanley B. Prusiner +11 more
TL;DR: It is argued that the PrP gene modulates scrapie susceptibility, incubation times, and neuropathology, and synthesis of infectious scrapie prions programmed by a recombinant DNA molecule is demonstrated.