K
Karen K. Hill
Researcher at Los Alamos National Laboratory
Publications - 59
Citations - 5570
Karen K. Hill is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Clostridium botulinum & Bacillus anthracis. The author has an hindex of 35, co-authored 59 publications receiving 5211 citations. Previous affiliations of Karen K. Hill include Texas Department of State Health Services & Northern Arizona University.
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Journal ArticleDOI
Small-Scale DNA Sample Preparation Method for Field PCR Detection of Microbial Cells and Spores in Soil
Cheryl R. Kuske,Kaysie L. Banton,Dante L. Adorada,Peter C. Stark,Karen K. Hill,Paul J. Jackson +5 more
TL;DR: A small-scale procedure to rapidly extract and purify DNA from soils was developed for in-the-field use and found that combining a hot-detergent treatment with bead mill homogenization gave the highest DNA yields from all three microbial cell types and provided DNA from the broadest range of microbial groups in a natural soil community.
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Sequence and Organization of pXO1, the Large Bacillus anthracis Plasmid Harboring the Anthrax Toxin Genes
Richard T. Okinaka,K. Cloud,Oliver A. Hampton,Alex R. Hoffmaster,Karen K. Hill,Paul Keim,Theresa M. Koehler,G. Lamke,Satoshi Kumano,Jacques Mahillon,Daniel K. Manter,Y. Martinez,Darrell O. Ricke,Rita Svensson,Paul J. Jackson +14 more
TL;DR: Among the ORFs with a high degree of similarity to known sequences are a collection of putative transposases, resolvases, and integrases, suggesting an evolution involving lateral movement of DNA among species.
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Genetic Diversity among Botulinum Neurotoxin-Producing Clostridial Strains
Karen K. Hill,Theresa J. Smith,Charles H. Helma,Lawrence O. Ticknor,Brian T. Foley,Rita Svensson,Jennifer L Brown,Eric A. Johnson,Leonard A. Smith,Richard T. Okinaka,Paul J. Jackson,James D. Marks +11 more
TL;DR: These analyses contribute to the understanding of the evolution and phylogeny within this species and assist in the development of improved diagnostics and therapeutics for the treatment of botulism.
Journal ArticleDOI
Molecular evolution and diversity in Bacillus anthracis as detected by amplified fragment length polymorphism markers
Paul Keim,Abdulahi Kalif,James M. Schupp,Karen K. Hill,Steven E. Travis,Kara L. Richmond,Debra M. Adair,Martin E. Hugh-Jones,Cheryl R. Kuske,Paul J. Jackson +9 more
TL;DR: Based on AFLP marker similarity, the ongoing anthrax epidemic in Canada and the northern United States is due to a single strain introduction that has remained stable over at least 30 years and a 1,000-mile distribution.
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Characterization of Bacillus cereus Isolates Associated with Fatal Pneumonias: Strains Are Closely Related to Bacillus anthracis and Harbor B. anthracis Virulence Genes
Alex R. Hoffmaster,Karen K. Hill,Jay E. Gee,Chung K. Marston,Barun K. De,Tanja Popovic,David Sue,Patricia P. Wilkins,Swati B. Avashia,Swati B. Avashia,Rahsaan Drumgoole,Charles H. Helma,Lawrence O. Ticknor,Richard T. Okinaka,Paul J. Jackson +14 more
TL;DR: The characterization of two clinical and one environmental B. cereus isolate collected during an investigation of two fatal pneumonia cases in Texas metal workers demonstrate that some B. Cereus strains can cause severe and even fatal infections in patients who appear to be otherwise healthy.