R
Richard T. Okinaka
Researcher at Northern Arizona University
Publications - 65
Citations - 4788
Richard T. Okinaka is an academic researcher from Northern Arizona University. The author has contributed to research in topics: Bacillus anthracis & Bacillus cereus. The author has an hindex of 32, co-authored 65 publications receiving 4589 citations. Previous affiliations of Richard T. Okinaka include Los Alamos National Laboratory.
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Journal ArticleDOI
Multiple-Locus Variable-Number Tandem Repeat Analysis Reveals Genetic Relationships within Bacillus anthracis
Paul Keim,Lance B. Price,A. M. Klevytska,K. L. Smith,K. L. Smith,J. M. Schupp,Richard T. Okinaka,Paul J. Jackson,Martin Hugh-Jones +8 more
TL;DR: A novel molecular typing system based on rapidly evolving variable-number tandem repeat (VNTR) loci is presented and six genetically distinct groups that appear to be derived from clones are identified.
Journal ArticleDOI
Sequence and Organization of pXO1, the Large Bacillus anthracis Plasmid Harboring the Anthrax Toxin Genes
Richard T. Okinaka,K. Cloud,Oliver A. Hampton,Alex R. Hoffmaster,Karen K. Hill,Paul Keim,Theresa M. Koehler,G. Lamke,Satoshi Kumano,Jacques Mahillon,Daniel K. Manter,Y. Martinez,Darrell O. Ricke,Rita Svensson,Paul J. Jackson +14 more
TL;DR: Among the ORFs with a high degree of similarity to known sequences are a collection of putative transposases, resolvases, and integrases, suggesting an evolution involving lateral movement of DNA among species.
Journal ArticleDOI
Genetic Diversity among Botulinum Neurotoxin-Producing Clostridial Strains
Karen K. Hill,Theresa J. Smith,Charles H. Helma,Lawrence O. Ticknor,Brian T. Foley,Rita Svensson,Jennifer L Brown,Eric A. Johnson,Leonard A. Smith,Richard T. Okinaka,Paul J. Jackson,James D. Marks +11 more
TL;DR: These analyses contribute to the understanding of the evolution and phylogeny within this species and assist in the development of improved diagnostics and therapeutics for the treatment of botulism.
Journal ArticleDOI
Global Genetic Population Structure of Bacillus anthracis
Matthew N. Van Ert,W. Ryan Easterday,Lynn Y. Huynh,Richard T. Okinaka,Richard T. Okinaka,Martin Hugh-Jones,Jacques Ravel,Shaylan Zanecki,Talima Pearson,Tatum S. Simonson,Jana M. U'Ren,Sergey Kachur,Rebecca R. Leadem-Dougherty,Shane D. Rhoton,Guenevier Zinser,Jason Farlow,Pamala R. Coker,Kimothy L. Smith,Bingxiang Wang,Leo J. Kenefic,Claire M. Fraser-Liggett,David M. Wagner,Paul Keim,Paul Keim,Paul Keim +24 more
TL;DR: Findings indicate humans have played an important role in the evolution of anthrax by increasing the proliferation and dispersal of this now global disease.
Journal ArticleDOI
Characterization of Bacillus cereus Isolates Associated with Fatal Pneumonias: Strains Are Closely Related to Bacillus anthracis and Harbor B. anthracis Virulence Genes
Alex R. Hoffmaster,Karen K. Hill,Jay E. Gee,Chung K. Marston,Barun K. De,Tanja Popovic,David Sue,Patricia P. Wilkins,Swati B. Avashia,Swati B. Avashia,Rahsaan Drumgoole,Charles H. Helma,Lawrence O. Ticknor,Richard T. Okinaka,Paul J. Jackson +14 more
TL;DR: The characterization of two clinical and one environmental B. cereus isolate collected during an investigation of two fatal pneumonia cases in Texas metal workers demonstrate that some B. Cereus strains can cause severe and even fatal infections in patients who appear to be otherwise healthy.