K
Karen L. Gamble
Researcher at University of Alabama at Birmingham
Publications - 94
Citations - 4166
Karen L. Gamble is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 32, co-authored 86 publications receiving 3445 citations. Previous affiliations of Karen L. Gamble include Vanderbilt University & Georgia State University.
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Journal ArticleDOI
Dysregulation of Inflammatory Responses by Chronic Circadian Disruption
Oscar Castanon-Cervantes,Mingwei Wu,J. Christopher Ehlen,Ketema N. Paul,Karen L. Gamble,Russell L. Johnson,Rachel C. Besing,Michael Menaker,Andrew T. Gewirtz,Alec J. Davidson +9 more
TL;DR: It is concluded that circadian disruption, but not sleep loss or stress, are associated with jet lag-related dysregulation of the innate immune system, which might be a common mechanism for the myriad negative health effects of shift work.
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Circadian clock control of endocrine factors
TL;DR: Observations suggest that strategies designed to realign normal circadian rhythmicities hold potential for the treatment of various endocrine-related disorders.
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Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision
Chad R. Jackson,Guo-Xiang Ruan,Fazila Aseem,Jane Abey,Karen L. Gamble,Gregg D. Stanwood,Richard D. Palmiter,Iuvone Pm,Douglas G. McMahon +8 more
TL;DR: It is indicated that dopamine is necessary for the circadian nature of light-adapted vision as well as optimal contrast detection and acuity and appears to be due to the ongoing bioavailability of dopamine rather than developmental effects.
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Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes.
Laura A. Volpicelli-Daley,Karen L. Gamble,Christine E. Schultheiss,Dawn M. Riddle,Andrew B. West,Virginia M.-Y. Lee +5 more
TL;DR: Pathological α-synuclein inclusions in axons impair transport of Rab7 and TrkB receptor-containing endosomes, as well as autophagosomes, while transport of synaptophysin and mitochondria is unaltered.
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Quantitative analysis of light-phase restricted feeding reveals metabolic dyssynchrony in mice
Molly S. Bray,William F. Ratcliffe,Maximiliano H. Grenett,Rachel A. Brewer,Karen L. Gamble,Martin E. Young +5 more
TL;DR: Weight gain following light (sleep)-phase restricted feeding is associated with significant alterations in energy balance, as well as dyssynchrony between metabolically active organs.