M
Martin E. Young
Researcher at University of Alabama at Birmingham
Publications - 218
Citations - 15559
Martin E. Young is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 66, co-authored 205 publications receiving 13957 citations. Previous affiliations of Martin E. Young include University of Alabama & United States Department of Agriculture.
Papers
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Journal ArticleDOI
Metabolic Gene Expression in Fetal and Failing Human Heart
Peter Razeghi,Martin E. Young,Joseph L. Alcorn,Christine S. Moravec,O.H. Frazier,Heinrich Taegtmeyer,Heinrich Taegtmeyer,Heinrich Taegtmeyer +7 more
TL;DR: In the human heart, metabolic genes exist as constitutive and inducible forms and the failing adult heart reverts to a fetal metabolic gene profile by downregulating adult gene transcripts rather than by upregulating fetal genes.
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Adaptation and Maladaptation of the Heart in Diabetes: Part I: General Concepts
TL;DR: The known trophic and hemodynamic effects of insulin in healthy individuals, the well-described endothelial dysfunction, the deposition of advanced glycation end products, and an accelerated progression of atherosclerosis in patients with diabetes add further complexities to the clinical picture of heart failure in diabetes.
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Adaptation and maladaptation of the heart in diabetes: Part II: Potential mechanisms
TL;DR: The prevailing concept of the heart’s response to changes in its environment is a complex network of inter-connecting signal transduction cascades, but changes in metabolic flux are extremely rapid, allowing them to act as signaling molecules.
Journal ArticleDOI
Increased Hepatic CD36 Expression Contributes to Dyslipidemia Associated With Diet-Induced Obesity
Debby P.Y. Koonen,René L. Jacobs,Maria Febbraio,Martin E. Young,Carrie Lynn M Soltys,Huy Ong,Dennis E. Vance,Jason R.B. Dyck +7 more
TL;DR: Increased expression of hepatic CD36 protein in response to DIO is sufficient to exacerbate hepatic triglyceride storage and secretion, suggesting that increased CD36 expression likely plays a causative role in the pathogenesis of type 2 diabetes.
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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression
Darrell D. Belke,Sandrine Betuing,Martin J. Tuttle,Christophe Graveleau,Martin E. Young,Mark Pham,Dongfang Zhang,Robert C. Cooksey,Donald A. McClain,Sheldon E. Litwin,Heinrich Taegtmeyer,David L. Severson,C. Ronald Kahn,E. Dale Abel +13 more
TL;DR: Insulin signaling plays an important developmental role in regulating postnatal cardiac size, myosin isoform expression, and the switching of cardiac substrate utilization from glucose to fatty acids.