K
Karin Zins
Researcher at Medical University of Vienna
Publications - 28
Citations - 956
Karin Zins is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Stromal cell & Cancer. The author has an hindex of 14, co-authored 23 publications receiving 857 citations. Previous affiliations of Karin Zins include University of Vienna.
Papers
More filters
Journal ArticleDOI
Colony-Stimulating Factor-1 Blockade by Antisense Oligonucleotides and Small Interfering RNAs Suppresses Growth of Human Mammary Tumor Xenografts in Mice
Seyedhossein Aharinejad,Patrick Paulus,Mouldy Sioud,Michael Hofmann,Karin Zins,Romana Schäfer,E. Richard Stanley,Dietmar Abraham +7 more
TL;DR: It is demonstrated that CSF-1 and CSF -1 receptor are potential therapeutic targets for the treatment of mammary cancer and mouse survival significantly increased after CSf-1 blockade.
Journal ArticleDOI
Colon Cancer Cell–Derived Tumor Necrosis Factor-α Mediates the Tumor Growth–Promoting Response in Macrophages by Up-regulating the Colony-Stimulating Factor-1 Pathway
TL;DR: Interrupting tumor cell-macrophage communication by targeting TNF-alpha may provide an alternative therapeutic approach for the treatment of colon cancer.
Journal ArticleDOI
A Rac1/Cdc42 GTPase-specific small molecule inhibitor suppresses growth of primary human prostate cancer xenografts and prolongs survival in mice.
TL;DR: A role of AZA1 in blocking Rac1/Cdc42-dependent cell cycle progression, cancer cell migration and increase of cancer cell apoptosis involving down-regulation of the AKT and PAK signaling pathway in prostate cancer cells is suggested.
Journal ArticleDOI
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity
TL;DR: The therapeutic potential of the small-molecule inhibitor AZA197 based on targeting Cdc42 GTPase activity to modulate colorectal cancer growth is indicated.
Journal ArticleDOI
Stromal cell-derived CSF-1 blockade prolongs xenograft survival of CSF-1-negative neuroblastoma
Dietmar Abraham,Karin Zins,Mouldy Sioud,Trevor Lucas,Romana Schäfer,E. Richard Stanley,Seyedhossein Aharinejad +6 more
TL;DR: It is demonstrated that increased CSF‐1 production by host cells enhances TAM recruitment and NB growth and that the CSf‐1 phenotype of NB tumor cells adversely affects survival.