Patrick Reichl

TL;DR: High Axl expression in HCC patient samples correlated with elevated vessel invasion of HCC cells, higher risk of tumor recurrence after liver transplantation, strong phosphorylation of Smad3L, and lower survival, and data suggest that Axl/14‐3‐3ζ signaling is central for TGF‐β‐mediated HCC progression and a promising target for HCC therapy.

TL;DR: This review aims at collecting recent findings on the impact of TGF-β-induced EMT in liver carcinoma progression and at discussing new insights on promising drugable targets for future therapeutic approaches against CCC and HCC.

TL;DR: A role of AZA1 in blocking Rac1/Cdc42-dependent cell cycle progression, cancer cell migration and increase of cancer cell apoptosis involving down-regulation of the AKT and PAK signaling pathway in prostate cancer cells is suggested.

TL;DR: Promising novel diagnostic serum protein biomarkers, such as annexin A2, the soluble form of the receptor tyrosine kinase Axl and thioredoxin are compared as well as their combinations with AFP to recapitulating the most recent developments in HCC biomarker research.

TL;DR: In this article, the potential of soluble axl (sAxl) as a biomarker of early hepatocellular carcinoma (HCC) was addressed by analyzing levels of sAxl in 311 HCC and 237 control serum samples from centers in Europe and China.