Karina Corware

TL;DR: The results suggest that increased arginase in lesions of patients with cutaneous leishmaniasis might play a role in the pathogenesis of the disease by impairing T cell effector functions.

TL;DR: The phenotype of arginase-expressing cells among PBMCs as neutrophils is identified and it is shown that their frequency was increased inPBMCs of patients before treatment; this coincides with reduced levels of L-arginine in the plasma and decreased expression levels of CD3ζ in T cells.

TL;DR: Using both low and high doses of parasites in the ears of BALB/c mice it is shown that the infections benefit from the presence of vector saliva and parasite gel in the skin, however, chronic infection of the spleen was only enhanced in high dose co-infections with gel.

TL;DR: A cost-effective AmB-PMA could be used to pharmacologically treat and immuno-therapeutically accelerate the healing of CL lesions and suggest that a water soluble, non-toxic, short course and low cost treatment exists.

TL;DR: It is shown that following protein energy malnutrition, the increased parasite burden measured in the spleen of these mice coincided with increased arginase activity and that macrophages provide a more permissive environment for parasite growth.