K
Karina Kramer
Researcher at Danube University Krems
Publications - 10
Citations - 60
Karina Kramer is an academic researcher from Danube University Krems. The author has contributed to research in topics: Chemistry & Mesenchymal stem cell. The author has an hindex of 3, co-authored 6 publications receiving 31 citations.
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Journal ArticleDOI
Characterization and Chondroprotective Effects of Extracellular Vesicles From Plasma- and Serum-Based Autologous Blood-Derived Products for Osteoarthritis Therapy
Alexander Otahal,Karina Kramer,Olga Kuten-Pella,René Weiss,Christoph Stotter,Zsombor Lacza,Viktoria Weber,Stefan Nehrer,Andrea De Luna +8 more
TL;DR: The results indicate that blood EVs are sufficient to induce chondrogenic gene expression changes in OA chondrocytes, while preventing proinflammatory cytokine release compared to full blood product.
Journal ArticleDOI
The Effect of Blood-Derived Products on the Chondrogenic and Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Originated from Three Different Locations.
Markus Neubauer,Olga Kuten,Christoph Stotter,Karina Kramer,Andrea De Luna,Thomas Muellner,Zsombor Lacza,Stefan Nehrer +7 more
TL;DR: Blood product preparation method, type of anticoagulant, differentiation time, and blood product concentration have a significant influence on stem cell viability and the differentiation potential, favouring no use of antICOagulation, shorter differentiation periods, and lower blood product concentrations.
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Functional repertoire of EV-associated miRNA profiles after lipoprotein depletion via ultracentrifugation and size exclusion chromatography from autologous blood products.
Alexander Otahal,Olga Kuten-Pella,Karina Kramer,Markus Neubauer,Zsombor Lacza,Stefan Nehrer,Andrea De Luna +6 more
TL;DR: An isolation protocol is developed for EVs from CPRP and hypACT that can also deplete lipoproteins, which are often co-isolated in EV research due to shared physical properties and to gain insights into the functional repertoire conveyed via EV-associated miRNAs.
Journal ArticleDOI
Effects of Extracellular Vesicles from Blood-Derived Products on Osteoarthritic Chondrocytes within an Inflammation Model
Alexander Otahal,Karina Kramer,Olga Kuten-Pella,Lukas B. Moser,Markus Neubauer,Zsombor Lacza,Stefan Nehrer,Andrea De Luna +7 more
TL;DR: In this paper, a co-culture system of primary OA chondrocytes and activated M1 macrophages was developed to model an OA joint in order to observe the effects of EVs in modulating the inflammatory environment.
Journal ArticleDOI
Optimization of Lyophilized Hyperacute Serum (HAS) as a Regenerative Therapeutic in Osteoarthritis.
Isabel Olmos Calvo,Olga Kuten-Pella,Karina Kramer,Ágnes Madár,Szilvia Takács,Dorottya Kardos,Diána Simon,Szabina Erdo-Bonyar,Timea Berki,Andrea De Luna,Stefan Nehrer,Zsombor Lacza +11 more
TL;DR: In this paper, the regenerative potential of different formulations of HAS, including lyophilized and hyaluronic acid combined versions, to obtain a stable and standardized therapeutic in osteoarthritis (OA), which may be able to overcome the variability limitations of platelet-rich plasma (PRP).