K
Karine Gonzales
Researcher at Max F. Perutz Laboratories
Publications - 2
Citations - 2336
Karine Gonzales is an academic researcher from Max F. Perutz Laboratories. The author has contributed to research in topics: Internal medicine & Cas9. The author has an hindex of 1, co-authored 1 publications receiving 2017 citations.
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CRISPR RNA maturation by trans -encoded small RNA and host factor RNase III
Elitza Deltcheva,Krzysztof Chylinski,Krzysztof Chylinski,Cynthia M. Sharma,Karine Gonzales,Yanjie Chao,Zaid Ahmed Pirzada,Maria R. Eckert,Jörg Vogel,Emmanuelle Charpentier,Emmanuelle Charpentier +10 more
TL;DR: In this article, tracrRNA, a trans-encoded small RNA with 24-nucleotide complementarity to the repeat regions of crRNA precursor transcripts, is shown to direct the maturation of crRNAs by the activities of the widely conserved endogenous RNase III and the CRISPR-associated Csn1 protein.
Journal ArticleDOI
Duodenal macrophages control dietary iron absorption via local degradation of transferrin.
Nyamdelger Sukhbaatar,Stephanie D. Fritsch,Monika Linke,S. Horer,Mario Mažić,Karine Gonzales,Jan Pascal Kahler,Carina Binder,Caroline Lassnig,Birgit Strobl,Mathias Mueller,Barbara Scheiber-Mojdehkar,Claudia Gundacker,S Dabsch,Renate Kain,Markus Hengstschläger,Steven H. L. Verhelst,Günter Weiss,Igor Theurl,Thomas Weichhart +19 more
TL;DR: In this article , the authors found that mice with a macrophage-specific deletion of the tuberous sclerosis complex 2 (Tsc2), a negative regulator of mTORC1, possessed various defects in iron metabolism including defective steady state erythropoiesis and a reduced saturation of transferrin with iron.