Nyamdelger Sukhbaatar

TL;DR: The first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues is reported and a negative correlation of global circular RNAs abundance and proliferation is discovered.

TL;DR: Findings show that the mTOR pathway integrates spatiotemporal information of the environmental and cellular energy status by regulating cellular metabolic responses to guide immune cell activation and generate a systemic understanding of the immune system.

TL;DR: It is found that activation of the metabolic checkpoint kinase mTORC1 in macrophages by deletion of the gene encoding tuberous sclerosis 2 (Tsc2) was sufficient to induce hypertrophy and proliferation, resulting in excessive granuloma formation in vivo.

TL;DR: The role of the distinct macrophage populations that contribute to efficient iron metabolism and important cellular and systemic mechanisms involved in iron-regulating processes are highlighted.

TL;DR: A spatiotemporal model is presented suggesting that the mTOR network integrates pattern recognition and growth factor receptor activation with nutritional information from the cell and surrounding tissue to support T cell stimulation and tolerance.