K
Karl A. Nath
Researcher at Mayo Clinic
Publications - 289
Citations - 19298
Karl A. Nath is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Kidney & Heme oxygenase. The author has an hindex of 75, co-authored 254 publications receiving 17628 citations. Previous affiliations of Karl A. Nath include University of Minnesota & Wake Forest University.
Papers
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Journal ArticleDOI
Ferritin: a cytoprotective antioxidant strategem of endothelium.
György Balla,Harry S. Jacob,József Balla,Murray D. Rosenberg,Karl A. Nath,Fred S. Apple,John W. Eaton,Gregory M. Vercellotti +7 more
TL;DR: It is concluded that endothelium and perhaps other cell types may be protected from oxidant damage through the iron sequestrant, ferritin.
Journal ArticleDOI
Tubulointerstitial changes as a major determinant in the progression of renal damage.
TL;DR: This report concludes with a review of interstitial fibrosis, a pathologic process regarded as an irreversible outcome from tubulointerstitial injury.
Journal ArticleDOI
Induction of heme oxygenase is a rapid, protective response in rhabdomyolysis in the rat
Karl A. Nath,György Balla,Gregory M. Vercellotti,József Balla,Harry S. Jacob,Michael Levitt,Mark E. Rosenberg +6 more
TL;DR: In vivo evidence is provided that induction of heme oxygenase coupled to ferritin synthesis is a rapid, protective antioxidant response, suggesting a therapeutic strategy for populations at a high risk for rhabdomyolysis.
Journal ArticleDOI
Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.
TL;DR: It is demonstrated that reduced ferrohemoglobin, while relatively innocuous to cultured endothelial cells, when oxidized to ferrihemoglobin (methemoglobin), greatly amplifies oxidant (H2O2)-mediated endothelial-cell injury.
Journal ArticleDOI
Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
John D. Belcher,Chunsheng Chen,Julia Nguyen,Liming Milbauer,Fuad Abdulla,Abdu I. Alayash,Ann Smith,Karl A. Nath,Robert P. Hebbel,Gregory M. Vercellotti +9 more
TL;DR: It is concluded that intravascular hemolysis in SCD releases heme that activates endothelial TLR4 signaling leading to WPB degranulation, NF-κB activation, and vaso-occlusion, and heme lethality.