K
Karl Agger
Researcher at University of Copenhagen
Publications - 21
Citations - 5161
Karl Agger is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Histone methyltransferase & Histone Demethylases. The author has an hindex of 16, co-authored 21 publications receiving 4754 citations. Previous affiliations of Karl Agger include Novo Nordisk Foundation & European Institute of Oncology.
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Journal ArticleDOI
UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development.
Karl Agger,Paul A. C. Cloos,Jesper Christensen,Diego Pasini,Simon Rose,Juri Rappsilber,Irina Issaeva,Eli Canaani,Anna Elisabetta Salcini,Kristian Helin +9 more
TL;DR: It is shown that the human JmjC-domain-containing proteins UTX and JMJD3 demethylate tri-methylated Lys 27 on histone H3, and the results suggest that H3K27me3 dem methylation regulated by UTX/JMJD3 proteins is essential for proper development.
Journal ArticleDOI
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
Paul A. C. Cloos,Jesper Christensen,Karl Agger,Alessio Maiolica,Juri Rappsilber,Torben L. Antal,Klaus Hansen,Kristian Helin +7 more
TL;DR: In addition to identifying GASC1 as a histone trimethyl demethylase, this work suggests a model for how this enzyme might be involved in cancer development, and proposes it as a target for anti-cancer therapy.
Journal ArticleDOI
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
TL;DR: The emerging biochemical and biological functions of the histone demethylases are reviewed and their potential involvement in human diseases, including cancer, is discussed.
Journal ArticleDOI
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3
Jesper Christensen,Karl Agger,Paul A. C. Cloos,Diego Pasini,Simon Rose,Lau Sennels,Juri Rappsilber,Klaus Hansen,Anna Elisabetta Salcini,Kristian Helin +9 more
TL;DR: It is demonstrated that the JARID1 proteins RBP2, PLU1, and SMCX are histone demethylases specific for di- and trimethylated histone 3 lysine 4 (H3K4) and that mutation or RNAi depletion of the C. elegans JARid1 homolog rbr-2 leads to increased levels of H3K 4me3 during larval development and defects in vulva formation.
Journal ArticleDOI
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A–ARF locus in response to oncogene- and stress-induced senescence
Karl Agger,Paul A. C. Cloos,Lise Rudkjaer,Kristine Williams,Gitte Andersen,Jesper Christensen,Kristian Helin +6 more
TL;DR: It is shown that expression of the histone H3 Lys 27 (H3K27) demethylase JMJD3 is induced upon activation of the RAS-RAF signaling pathway and contributes to the transcriptional activation of p16INK4A in human diploid fibroblasts.