K
Karl J. Guegler
Researcher at Applied Biosystems
Publications - 9
Citations - 4810
Karl J. Guegler is an academic researcher from Applied Biosystems. The author has contributed to research in topics: Polynucleotide & Association mapping. The author has an hindex of 5, co-authored 9 publications receiving 4476 citations.
Papers
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Journal ArticleDOI
Real-time quantification of microRNAs by stem–loop RT–PCR
Caifu Chen,Dana Ridzon,Adam Broomer,Zhaohui Zhou,Danny H. Lee,Julie T. Nguyen,Maura Barbisin,Nan Lan Xu,Vikram R. Mahuvakar,Mark R. Andersen,Kaiqin Lao,Kenneth J. Livak,Karl J. Guegler +12 more
TL;DR: A novel microRNA quantification method has been developed using stem–loop RT followed by TaqMan PCR analysis, which enables fast, accurate and sensitive miRNA expression profiling and can identify and monitor potential biomarkers specific to tissues or diseases.
Journal ArticleDOI
The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern
Francisco M. De La Vega,Hadar Isaac,Andrew Collins,Charles R. Scafe,Bjarni V. Halldorsson,Bjarni V. Halldorsson,Xiaoping Su,Ross A. Lippert,Ross A. Lippert,Yu Wang,Marion Laig-Webster,Ryan T. Koehler,Janet S. Ziegle,Lewis T. Wogan,Junko Stevens,Kyle M. Leinen,Sheri J. Olson,Karl J. Guegler,Xiaoqing You,Lily Xu,Heinz G. Hemken,Francis Kalush,Mitsuo Itakura,Yi Zheng,Stephen J. O'Brien,Andrew G. Clark,Sorin Istrail,Michael W. Hunkapiller,Eugene G. Spier,Dennis A. Gilbert +29 more
TL;DR: A comparison of the patterns of LD across four major human populations with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22 and the long-range contour is remarkably similar across the four populations.
Journal Article
Recreational music-making modulates the human stress response: a preliminary individualized gene expression strategy.
Barry Bittman,Lee Berk,Mark Shannon,Muhammad Sharaf,Jim Westengard,Karl J. Guegler,David Ruff +6 more
TL;DR: Modulation of individualized genomic stress induction signatures in peripheral blood presents a new opportunity for elucidating the dynamics of the human stress response.
Patent
Method to Quantify siRNAs, miRNAs and Polymorphic miRNAs
TL;DR: In this article, a reverse stem-loop ligation probe is ligated to the 3' end of a target polynucleotide, using a ligase that can ligate from 3' to 5' using a DNA template, such as T4 DNA ligase.
Patent
Methods and compositions for pcr using blocked and universal primers
Eugene G. Spier,Karl J. Guegler +1 more
TL;DR: In this article, methods and compositions for performing PCR with primers with blocked 3′-ends that are unblocked when these primers anneal to the template are presented.