Karl-Otto Stetter

TL;DR: The crystal structure of the thermosome, the archaeal group II chaperonin from T. acidophilum is determined to 2.6 A resolution and Binding of the transition state analog Mg-ADP-AIF3 suggests that the closed conformation corresponds to the ATP form.

TL;DR: The data suggest that the ancestral enzyme was put together from subunits that previously had played a role in other electron transfer chains and a localised modification of previous tree topologies is proposed on the basis of the obtained data.

TL;DR: The reductive citric acid cycle for autotrophic CO2 fixation now has been documented in the eubacterial branches of the proteobacteria, in green sulfur bacteria, and in the thermophilic Knallgas bacteria as well as in the branch of the sulfur dependent archaebacteria.

TL;DR: Investigation of the pathway of autotrophic CO2 fixation in the phototrophic bacterium Chloroflexus aurantiacus and in the aerobic thermoacidophilic archaeon Metallosphaera sedula suggested that the aerobicautotrophic archaea M. sedula, S. metallicus, and A. infernus use a yet-to-be-defined 3-hydroxypropionate cycle for their Autotrophic growth.

TL;DR: It is demonstrated that all three hydrogenases are expressed under standard growth conditions of the organism and a model for the metabolic roles of the three enzymes is proposed on the basis of the obtained results.