Karla Vazquez-Santillan

TL;DR: Several recurrent genomic alterations in cervical carcinomas are demonstrated that suggest new strategies to combat this disease.

TL;DR: lncRNAs are valuable tools in the search for new targets to selectively eliminate CSCs and improve clinical outcomes and may serve as excellent therapeutic targets because they are stable, easily detectable and expressed in tissue-specific contexts.

TL;DR: Targeted disruption of the NF-κB signaling pathway may profoundly impair the adverse phenotype of CSCs and may provide a therapeutic opportunity to remove the CSC fraction, and recent evidence shows that such targeted strategies may be useful in adjuvant chemo-preventive settings.

TL;DR: The results support the essential involvement of NIK in BCSC phenotypic regulation via ERK1/2 and NF-κB and the in vivo relevance is further supported by a tissue microarray of breast cancer samples in which it is observed correlated expression of Aldehyde dehydrogenase (ALDH) and NIK protein.

TL;DR: It is reported for the first time that MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients, however additional clinical studies must be performed to confirm the findings as new probable clinical markers in NSclC patients.