Karol Macura

TL;DR: In this article, the lateral mesoderm-specific lncRNA Fendrr was found to be essential for proper heart and body wall development in the mouse, and the upregulation of several transcription factors was associated with a drastic reduction in PRC2 occupancy along with decreased H3K27 trimethylation.

TL;DR: A global analysis of NMPs and their descending lineages performed on purified cells from embryonic day 8.5 wild-type and mutant embryos shows that T, cooperatively with WNT signaling, controls the progenitor state and the switch toward the mesodermal fate.

TL;DR: An integrated vector system for inducible gene silencing by shRNAmir-mediated RNA interference in mouse embryos is developed, as a fast method for dissecting mammalian gene function, and provides tight control of the genetic background minimizing intrinsic variation.

TL;DR: The ability to generatePSM cells of either posterior or anterior PSM identity with high efficiency in vitro will promote the investigation of the gene regulatory networks controlling the formation of nascent PSM cells and their switch to differentiating/somitic paraxial mesoderm.

TL;DR: It is shown that cooperative function of BRACHYURY (T) with histone‐modifying enzymes is essential for mouse embryogenesis, and that T plays a prominent role in the specification of hematopoietic and endothelial cell types.