M
Markus Morkel
Researcher at Humboldt University of Berlin
Publications - 58
Citations - 2174
Markus Morkel is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Wnt signaling pathway & Colorectal cancer. The author has an hindex of 20, co-authored 46 publications receiving 1642 citations. Previous affiliations of Markus Morkel include Humboldt State University & German Cancer Research Center.
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Journal ArticleDOI
c-Met is essential for wound healing in the skin
Jolanta Chmielowiec,Malgorzata Borowiak,Markus Morkel,Theresia E. B. Stradal,Barbara Munz,Sabine Werner,Jürgen Wehland,Carmen Birchmeier,Walter Birchmeier +8 more
TL;DR: The data show that c-Met signaling not only controls cell growth and migration during embryogenesis but is also essential for the generation of the hyperproliferative epithelium in skin wounds, and thus for a fundamental regenerative process in the adult.
Journal ArticleDOI
MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments
TL;DR: This work presents a major update of the R/Bioconductor package MEDIPS, which allows for an arbitrary number of replicates per group and integrates sophisticated statistical methods for the detection of differential coverage between experimental conditions.
Journal ArticleDOI
β-Catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
Markus Morkel,Joerg Huelsken,Maki Wakamiya,Jixiang Ding,Marc van de Wetering,Hans Clevers,Makoto Mark Taketo,Richard R. Behringer,Michael M. Shen,Walter Birchmeier +9 more
TL;DR: In this paper, gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development.
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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals.
Nils C. Gassen,Jan Papies,Jan Papies,Thomas Bajaj,Jackson Emanuel,Jackson Emanuel,Frederik Dethloff,Robert Lorenz Chua,Jakob Trimpert,Nicolas Heinemann,Nicolas Heinemann,Christine Niemeyer,Friderike Weege,Friderike Weege,Katja Hönzke,Tom Aschman,Daniel E. Heinz,Katja Weckmann,Tim Ebert,Andreas Zellner,M. Lennarz,Emanuel Wyler,Simon Schroeder,Simon Schroeder,Anja Richter,Anja Richter,Daniela Niemeyer,Daniela Niemeyer,Karen Hoffmann,Thomas F. Meyer,Frank L. Heppner,Frank L. Heppner,Victor M. Corman,Victor M. Corman,Markus Landthaler,Markus Landthaler,Andreas C. Hocke,Markus Morkel,Markus Morkel,Nikolaus Osterrieder,Nikolaus Osterrieder,Christian Conrad,Roland Eils,Roland Eils,Helena Radbruch,Patrick Giavalisco,Christian Drosten,Christian Drosten,Marcel A. Müller +48 more
TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.
Journal ArticleDOI
An E2F-like repressor of transcription
TL;DR: An E2F-like protein is described, termed EMA (for E 2F-binding site modulating activity), which can act as a repressor of transcription without a pocket protein.