Kassie Koleckar

TL;DR: It is reported that chronic inflammation resulting from severe dermatitis or autoimmune encephalitis leads to robust fusion of BMDCs with Purkinje neurons and formation of hundreds of binucleate heterokaryons per cerebellum, a 10–100-fold higher frequency than previously reported.

TL;DR: The results validate the hydrogel microwell platform as a broadly applicable paradigm for dissecting the regulatory role of specific signals within a complex stem cell niche and provide evidence of self-renewal divisions of HSCs in vitro.

TL;DR: In this paper, the authors used traction force microscopy to investigate the role of fibrotic stiffening in the etiology of Duchenne muscular dystrophy (DMD) cardiomyopathy.

TL;DR: ConTraX as discussed by the authors is an open-access, versatile, streamlined, and highly automated pipeline to address these challenges and enable quantitative tracking of the contractile dynamics of single human induced pluripotent stem cells over time.

TL;DR: It is found that TRF2 upregulation in DMD cardiomyocytes increased telomere lengths, cell size, nuclear size, sarcomere density, and cell survival, which suggest TRF 2 gene therapy has the potential to delay the onset of dilated cardiopathy.