Kate H C Gowers

TL;DR: A wider role for IL-25 is delineated in mediating structural changes to the lung following allergen exposure and this work implicatesIL-25 as a novel therapeutic target for the treatment of airway remodelling in asthma.

TL;DR: Using a murine model of fragility fractures, it is found that local rhTNF treatment improved fracture healing during the early phase of repair, which would reduce the morbidity and mortality associated with delayed patient mobilization.

TL;DR: The findings suggest that novel strategies to reduce the expression and activation of HIF-1α in lung macrophages may be used to attenuate allergen-induced airway inflammation and angiogenesis through the modulation of VEGF-A and CXCL1 expression.

TL;DR: This is the first demonstration that a pDNA vector can confer sustained episomal luciferase transgene expression in various mouse tumour models and can thus be readily utilised to follow tumour formation without interfering with the cellular genome.

TL;DR: It is shown that β3 adrenergic agonists (β3AR) in combination with a CXCR4 antagonist, AMD3100/Plerixafor, can mobilise MSCs into the blood in mice and rats and evidence is provided that this pharmacological strategy for MSC mobilisation enhances bone formation.