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Carla P. Jones
Researcher at National Institutes of Health
Publications - 22
Citations - 1409
Carla P. Jones is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Bone marrow & Progenitor cell. The author has an hindex of 15, co-authored 21 publications receiving 1255 citations. Previous affiliations of Carla P. Jones include Wellcome Trust Sanger Institute & Federal University of Rio de Janeiro.
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Journal ArticleDOI
Differential Mobilization of Subsets of Progenitor Cells from the Bone Marrow
TL;DR: It is shown that distinct factors and mechanisms regulate the mobilization of endothelial (EPCs) and stromal progenitor cells (SPCs) and that differential mobilization of progenitors cell subsets is dependent upon the cytokine milieu that regulates cell retention and proliferation.
Journal ArticleDOI
IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.
Jennifer Kearley,Jonas S. Erjefält,Cecilia Andersson,Ebony Benjamin,Carla P. Jones,Annette Robichaud,Sophie Pegorier,Yambasu A. Brewah,Timothy Burwell,Leif Bjermer,Peter A. Kiener,Roland Kolbeck,Clare M. Lloyd,Anthony J. Coyle,Alison A. Humbles +14 more
TL;DR: The data suggest an important role for an IL-9-MC axis in the pathology associated with chronic asthma and demonstrate that an impact on this axis could lead to a reduction in chronic inflammation and improved lung function in patients with asthma.
Journal ArticleDOI
IL-25 drives remodelling in allergic airways disease induced by house dust mite
Lisa G. Gregory,Carla P. Jones,Simone A. Walker,Devika Sawant,Kate H C Gowers,Gaynor A. Campbell,Andrew N. J. McKenzie,Clare M. Lloyd +7 more
TL;DR: A wider role for IL-25 is delineated in mediating structural changes to the lung following allergen exposure and this work implicatesIL-25 as a novel therapeutic target for the treatment of airway remodelling in asthma.
Journal ArticleDOI
Activin A and TGF-β promote TH9 cell–mediated pulmonary allergic pathology
TL;DR: A distinct functional role for T(H)9 cells is identified and a novel pathway for their generation in vitro and in vivo is outlined, which promotes allergic responses resulting in enhanced pathology mediated by the specific recruitment and activation of mast cells in the lungs.
Journal ArticleDOI
Quantifying the contribution of recessive coding variation to developmental disorders.
Hilary C. Martin,Wendy D Jones,Wendy D Jones,Rebecca E. McIntyre,Gabriela Sánchez-Andrade,Mark Sanderson,James Stephenson,James Stephenson,Carla P. Jones,Juliet Handsaker,Giuseppe Gallone,Michaela Bruntraeger,Jeremy F. McRae,Elena Prigmore,Patrick J. Short,Mari Niemi,Joanna Kaplanis,Elizabeth J. Radford,Elizabeth J. Radford,Nadia Akawi,Meena Balasubramanian,John Dean,Rachel Horton,Alice Hulbert,Diana S. Johnson,Katie Johnson,Dhavendra Kumar,Sally Ann Lynch,Sarju G. Mehta,Jenny Morton,Michael J. Parker,Miranda Splitt,Peter D. Turnpenny,Pradeep C. Vasudevan,Michael Wright,Andrew R. Bassett,Sebastian S. Gerety,Caroline F. Wright,David R. FitzPatrick,Helen V. Firth,Helen V. Firth,Matthew E. Hurles,Jeffrey C. Barrett +42 more
TL;DR: The results suggest that recessive coding variants account for a small fraction of currently undiagnosed nonconsanguineous individuals, and that the role of noncoding variants, incomplete penetrance, and polygenic mechanisms need further exploration.