A
Anna Nicolaou
Researcher at Manchester Academic Health Science Centre
Publications - 161
Citations - 5257
Anna Nicolaou is an academic researcher from Manchester Academic Health Science Centre. The author has contributed to research in topics: Polyunsaturated fatty acid & Homocysteine. The author has an hindex of 38, co-authored 145 publications receiving 4485 citations. Previous affiliations of Anna Nicolaou include University College London & University of Bradford.
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Journal ArticleDOI
The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy
Martin J. Hoogduijn,Felix C. Popp,Richard Verbeek,Mojgan Masoodi,Anna Nicolaou,Carla C. Baan,Marc H. Dahlke +6 more
TL;DR: Some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models are reviewed, new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins are presented and the hopes and expectations of MSC-based immune therapy are discussed.
Journal ArticleDOI
Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2.
Alastair O'Brien,James N. Fullerton,Karen A. Massey,Grace Auld,Gavin W. Sewell,Sarah James,Justine Newson,Effie Karra,Alison Winstanley,William Alazawi,Rita García-Martínez,Joan Cordoba,Anna Nicolaou,Derek W. Gilroy +13 more
TL;DR: Treatment with COX inhibitors or albumin restored immune competence and survival following infection with group B Streptococcus and taken together, human albumin solution infusions may be used to reduce circulating PGE2 levels, attenuating immune suppression and reducing the risk of infection in patients with acutely decompensated cirrhosis or ESLD.
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Bioactive lipid mediators in skin inflammation and immunity
TL;DR: This work focuses on psoriasis, atopic and contact dermatitis, acne vulgaris, wound healing and photodermatology that demonstrate dysregulation of bioactive lipid metabolism and examine ways of using this insight to inform novel therapeutics.
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Lipidomic analysis of twenty‐seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry
Mojgan Masoodi,Anna Nicolaou +1 more
TL;DR: The LC/ESI-MS/MS assay can be applied to the profiling of prostanoids produced by a variety of biological fluids and extracts including brain, liver, plasma and urine, thus facilitating the understanding of the role of these lipid mediators in health and disease, as well as assisting in drug development.
Journal ArticleDOI
Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy-fatty acids by liquid chromatography/electrospray ionisation tandem mass spectrometry.
TL;DR: An LC/ESI-MS/MS assay for the simultaneous analysis of twenty mono- and poly-hydroxy-fatty acid derivatives of linoleic, arachidonic, eicosapentaenoic and docosahexaenoic acids is presented to advance the understanding of the role of PUFA in health and disease.