K
Katharina Rox
Publications - 16
Citations - 2392
Katharina Rox is an academic researcher. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 2, co-authored 2 publications receiving 1523 citations.
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Journal ArticleDOI
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
Linlin Zhang,Daizong Lin,Xinyuanyuan Sun,Ute Curth,Christian Drosten,Lucie Sauerhering,Stephan Becker,Katharina Rox,Rolf Hilgenfeld +8 more
TL;DR: The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route and work that may provide a basis for development of anticoronaviral drugs.
Posted ContentDOI
X-ray Structure of Main Protease of the Novel Coronavirus SARS-CoV-2 Enables Design of α-Ketoamide Inhibitors
TL;DR: The crystal structure of the unliganded Mpro was determined at 1.75 Å resolution and used to guide optimization of a series of alpha-ketoamide inhibitors, which will form the basis for further development of these compounds to antiviral drugs.
Journal ArticleDOI
Lectin-Targeted Prodrugs Activated by Pseudomonas aeruginosa for Self-Destructive Antibiotic Release
TL;DR: This work has established the first lectin-targeted antibiotic prodrugs against P. aeruginosa, which showed good absorption, distribution, metabolism, and elimination (ADME) properties and reduced toxicity in vitro.
Journal ArticleDOI
Identification of Antimotilins, Novel Inhibitors of Helicobacter pylori Flagellar Motility That Inhibit Stomach Colonization in a Mouse Model
Sebastian Suerbaum,Nina Coombs,Lubna Patel,Dimitri Pscheniza,Katharina Rox,Christine S. Falk,Achim D. Gruber,Olivia Kershaw,Patrick Chhatwal,Mark Brönstrup,Ursula Bilitewski,Christine Josenhans +11 more
TL;DR: A screening system for inhibitors of H. pylori motility and flagellar assembly was developed, and numerous novel antibacterial and anti-motility compounds (antimotilins) were identified.
Journal ArticleDOI
Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
M. Cooper,Linlin Zhang,M. Ibrahim,Kaixuan Zhang,Xin-Kuan Sun,Judith Röske,Matthias Göhl,Mark Brönstrup,Justin K. Cowell,Lucie Sauerhering,Stephan Beck,Laura Vangeel,Dirk Jochmans,Johan Neyts,Katharina Rox,Graham P. Marsh,Hannah Maple,Rolf Hilgenfeld +17 more
TL;DR: The diastereomeric resolution of the previously designed SARS-CoV-2 Mpro α-ketoamide inhibitor 13b is reported, and the active inhibitor (13b-K) is a promising candidate for further development as an antiviral treatment for COVID-19.