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Alexander Titz
Researcher at Saarland University
Publications - 68
Citations - 1681
Alexander Titz is an academic researcher from Saarland University. The author has contributed to research in topics: Pseudomonas aeruginosa & Lectin. The author has an hindex of 19, co-authored 55 publications receiving 1049 citations. Previous affiliations of Alexander Titz include University of Bordeaux & University of Konstanz.
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Journal ArticleDOI
Towards the sustainable discovery and development of new antibiotics
Marcus Miethke,Marco Pieroni,Tilmann Weber,Mark Brönstrup,Peter Hammann,Ludovic Halby,Paola B. Arimondo,Philippe Glaser,Bertrand Aigle,Helge B. Bode,Helge B. Bode,Rui Moreira,Yanyan Li,Andriy Luzhetskyy,Marnix H. Medema,Jean-Luc Pernodet,Marc Stadler,José R. Tormo,Olga Genilloud,Andrew W. Truman,Kira J. Weissman,Eriko Takano,Stefano Sabatini,Evi Stegmann,Heike Brötz-Oesterhelt,Wolfgang Wohlleben,Myriam Seemann,Martin Empting,Anna K. H. Hirsch,Brigitta Loretz,Claus-Michael Lehr,Alexander Titz,Jennifer Herrmann,Timo Jaeger,Silke Alt,Thomas Hesterkamp,Mathias Winterhalter,Andrea Schiefer,Kenneth Pfarr,Achim Hoerauf,Heather Graz,Michael Graz,Mika Lindvall,Savithri Ramurthy,Anders Karlén,Maarten van Dongen,Hrvoje Petković,Andreas Keller,Frédéric Peyrane,Stefano Donadio,Laurent Fraisse,Laura J. V. Piddock,Ian H. Gilbert,Heinz E. Moser,Rolf Müller +54 more
TL;DR: In this paper, the authors present a strategic blueprint to substantially improve our ability to discover and develop new antibiotics, and propose both short-term and long-term solutions to overcome the most urgent limitations in the various sectors of research and funding.
Journal ArticleDOI
Novel Strategies for the Treatment of Pseudomonas aeruginosa Infections
Stefanie Wagner,Roman Sommer,Stefan Hinsberger,Cenbin Lu,Rolf W. Hartmann,Martin Empting,Alexander Titz +6 more
TL;DR: It can be expected that combination therapies, also containing antivirulence agents, will pave the way toward novel treatment options against P. aeruginosa, and antivirulent drugs are expected to yield a significantly reduced rate of resistance development.
Journal ArticleDOI
Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa
Roman Sommer,Stefanie Wagner,Katharina Rox,Annabelle Varrot,Dirk Hauck,Eike-Christian Wamhoff,Janine Schreiber,Thomas Ryckmans,Thomas Brunner,Christoph Rademacher,Rolf W. Hartmann,Mark Brönstrup,Anne Imberty,Alexander Titz +13 more
TL;DR: A new class of drug-like low molecular weight inhibitors of the lectin LecB with nanomolar affinities and excellent receptor binding kinetics and thermodynamics is reported, efficiently blocked biofilm formation of P. aeruginosa in vitro while the natural monovalent carbohydrate ligands failed.
Journal ArticleDOI
Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes
Dirk Hauck,Ines Joachim,Benjamin Frommeyer,Annabelle Varrot,Bodo Philipp,Heiko M. Möller,Anne Imberty,Thomas E. Exner,Alexander Titz +8 more
TL;DR: Cinnamide and sulfonamide derivatives are inhibitors of bacterial adhesion with up to a 20-fold increase in affinity to LecB compared to the natural ligand methyl mannoside and capped structures as reported here may offer a beneficial selectivity profile for the pathogenic lectin.
Journal ArticleDOI
A safe and convenient method for the preparation of triflyl azide, and its use in diazo transfer reactions to primary amines
TL;DR: In this paper, a safe and convenient method for the copper(II)-catalyzed diazo transfer from triflyl azide to primary amines is reported.