K
Katherine C. Helming
Researcher at Harvard University
Publications - 6
Citations - 935
Katherine C. Helming is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin remodeling & SWI/SNF. The author has an hindex of 5, co-authored 6 publications receiving 745 citations. Previous affiliations of Katherine C. Helming include Boston Children's Hospital.
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Journal ArticleDOI
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Katherine C. Helming,Xiaofeng Wang,Boris G. Wilson,Francisca Vazquez,Jeffrey R. Haswell,Haley E. Manchester,Youngha Kim,Gregory V. Kryukov,Mahmoud Ghandi,Andrew J. Aguirre,Zainab Jagani,Zhong Wang,Levi A. Garraway,William C. Hahn,Charles W. M. Roberts +14 more
TL;DR: It is found that loss of ARID1B in AR ID1A-deficient backgrounds destabilizes SWI/SNF and impairs proliferation in both cancer cells and primary cells, and is identified as a potential therapeutic target for ARID 1A-mutant cancers.
Journal ArticleDOI
Vulnerabilities of mutant SWI/SNF complexes in cancer.
Katherine C. Helming,Xiaofeng Wang,Xiaofeng Wang,Charles W. M. Roberts,Charles W. M. Roberts +4 more
TL;DR: Emerging data that loss-of-function mutations lead to the formation of aberrant residual SWI/SNF complexes that constitute a specific vulnerability are discussed and the potential for exploiting these dependencies in SWI-SNF mutant cancers is discussed.
Journal ArticleDOI
Residual Complexes Containing SMARCA2 (BRM) Underlie the Oncogenic Drive of SMARCA4 (BRG1) Mutation
Boris G. Wilson,Katherine C. Helming,Xiaofeng Wang,Youngha Kim,Francisca Vazquez,Francisca Vazquez,Zainab Jagani,William C. Hahn,William C. Hahn,Charles W. M. Roberts +9 more
TL;DR: A role for SMARCA2 in oncogenesis caused bySMARCA4 loss is revealed and the ATPase and bromodomain-containing SMAR CA2 is identified as a potential therapeutic target in these cancers.
Journal ArticleDOI
Swi/Snf chromatin remodeling/tumor suppressor complex establishes nucleosome occupancy at target promoters
Michael Y. Tolstorukov,Courtney G. Sansam,Courtney G. Sansam,Ping Lu,Ping Lu,Edward C. Koellhoffer,Edward C. Koellhoffer,Katherine C. Helming,Katherine C. Helming,Burak H. Alver,Erik J. Tillman,Erik J. Tillman,Julia A. Evans,Julia A. Evans,Boris G. Wilson,Boris G. Wilson,Peter J. Park,Peter J. Park,Charles W. M. Roberts,Charles W. M. Roberts +19 more
TL;DR: It is found that inactivation of either subunit of the mammalian Swi/Snf complex leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosomes occupancy at a large number of promoters, regardless of their association with CpG islands.
Proceedings ArticleDOI
Abstract LB-126: ARID1B is a specific vulnerability in ARID1A-mutant cancers
Katherine C. Helming,Xiaofeng Wang,Boris G. Wilson,Francisca Vazquez,Jeffrey R. Haswell,Haley E. Manchester,Youngha Kim,Gregory V. Kryukov,Mahmoud Ghandi,Andrew J. Aguirre,Zainab Jagani,Zhong Wang,Levi A. Garraway,William C. Hahn,Charles W. M. Roberts +14 more
TL;DR: It is demonstrated that cancer cell lines harboring mutations in ARID1A are specifically dependent upon ARIDs1B and insight is provided into the structural role of ARid1A/B in the SWI/SNF chromatin remodeling complex.