Z
Zhong Wang
Researcher at University of Michigan
Publications - 17
Citations - 1672
Zhong Wang is an academic researcher from University of Michigan. The author has contributed to research in topics: Chromatin remodeling & Cellular differentiation. The author has an hindex of 13, co-authored 17 publications receiving 1460 citations. Previous affiliations of Zhong Wang include University of California, Berkeley & Harvard University.
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Journal ArticleDOI
ARID1B is a specific vulnerability in ARID1A-mutant cancers
Katherine C. Helming,Xiaofeng Wang,Boris G. Wilson,Francisca Vazquez,Jeffrey R. Haswell,Haley E. Manchester,Youngha Kim,Gregory V. Kryukov,Mahmoud Ghandi,Andrew J. Aguirre,Zainab Jagani,Zhong Wang,Levi A. Garraway,William C. Hahn,Charles W. M. Roberts +14 more
TL;DR: It is found that loss of ARID1B in AR ID1A-deficient backgrounds destabilizes SWI/SNF and impairs proliferation in both cancer cells and primary cells, and is identified as a potential therapeutic target for ARID 1A-mutant cancers.
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ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a.
TL;DR: DNA microarray, immunostaining, and RNA analyses revealed that BAF250a-mediated chromatin remodeling contributes to the proper expression of numerous genes involved in ES cell self-renewal, including Sox2, Utf1, and Oct4, and the pluripotency defects in BAF 250a mutant ES cells appear to be cell lineage-specific.
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Lives of a heart cell: tracing the origins of cardiac progenitors.
TL;DR: This review highlights recent clarifications, revisions, and advances in the understanding of the many lives of a heart cell, with a primary focus on the emerging links between cardiogenesis and heart stem cell biology.
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Polybromo protein BAF180 functions in mammalian cardiac chamber maturation
Zhong Wang,Weiguo Zhai,James A. Richardson,Eric N. Olson,Juanito J. Meneses,Meri T. Firpo,Chulho Kang,William C. Skarnes,William C. Skarnes,Robert Tjian +9 more
TL;DR: It is shown that the ablation of PBAF-specific subunit BAF180 in mouse embryos results in severe hypoplastic ventricle development and trophoblast placental defects, similar to those found in mice lacking RXRalpha and PPARgamma.
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BAF250B-associated SWI/SNF chromatin-remodeling complex is required to maintain undifferentiated mouse embryonic stem cells.
Zhijiang Yan,Zhong Wang,Lioudmila V. Sharova,Alexei A. Sharov,Chen Ling,Yulan Piao,Kazuhiro Aiba,Ryo Matoba,Weidong Wang,Minoru S.H. Ko +9 more
TL;DR: The work presented here underscores the importance of SWI/SNF chromatin remodeling complexes in pluripotent stem cells, and suggests that the BAF250B‐associated SWF is essential for mouse ES cells to maintain their normal proliferation and pluripotency.