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Katherine J Phelps
Researcher at University of Texas Southwestern Medical Center
Publications - 1
Citations - 598
Katherine J Phelps is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: DNA damage & Myocyte. The author has an hindex of 1, co-authored 1 publications receiving 451 citations.
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The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.
Bao N. Puente,Wataru Kimura,Shalini Muralidhar,Jesung Moon,James F. Amatruda,Katherine J Phelps,David Grinsfelder,Beverly A. Rothermel,Rui Chen,Joseph A. Garcia,Celio X.C. Santos,Suwannee Thet,Eiichiro Mori,Michael Kinter,Paul M. Rindler,Serena Zacchigna,Shibani Mukherjee,David J. Chen,Ahmed I. Mahmoud,Mauro Giacca,Peter S. Rabinovitch,Asaithamby Aroumougame,Ajay M. Shah,Luke I. Szweda,Hesham A. Sadek +24 more
TL;DR: It is shown that reactive oxygen species (ROS), oxidative DNA damage, and DNA damage response (DDR) markers significantly increase in the heart during the first postnatal week, revealing a protective mechanism that mediates cardiomyocyte cell-cycle arrest in exchange for utilization of oxygen-dependent aerobic metabolism.