W
Wataru Kimura
Researcher at University of Texas Southwestern Medical Center
Publications - 40
Citations - 3107
Wataru Kimura is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Gastrulation & Endoderm. The author has an hindex of 18, co-authored 37 publications receiving 2458 citations. Previous affiliations of Wataru Kimura include Hamamatsu University & University of Tsukuba.
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The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response.
Bao N. Puente,Wataru Kimura,Shalini Muralidhar,Jesung Moon,James F. Amatruda,Katherine J Phelps,David Grinsfelder,Beverly A. Rothermel,Rui Chen,Joseph A. Garcia,Celio X.C. Santos,Suwannee Thet,Eiichiro Mori,Michael Kinter,Paul M. Rindler,Serena Zacchigna,Shibani Mukherjee,David J. Chen,Ahmed I. Mahmoud,Mauro Giacca,Peter S. Rabinovitch,Asaithamby Aroumougame,Ajay M. Shah,Luke I. Szweda,Hesham A. Sadek +24 more
TL;DR: It is shown that reactive oxygen species (ROS), oxidative DNA damage, and DNA damage response (DDR) markers significantly increase in the heart during the first postnatal week, revealing a protective mechanism that mediates cardiomyocyte cell-cycle arrest in exchange for utilization of oxygen-dependent aerobic metabolism.
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Hypoxia induces heart regeneration in adult mice
Yuji Nakada,Diana C. Canseco,Suwannee Thet,Salim Abdisalaam,Aroumougame Asaithamby,Celio X.C. Santos,Ajay M. Shah,Hua Zhang,James E. Faber,Michael Kinter,Luke I. Szweda,Chao Xing,Zeping Hu,Ralph J. DeBerardinis,Gabriele G. Schiattarella,Joseph A. Hill,Orhan K. Öz,Zhigang Lu,Cheng Cheng Zhang,Wataru Kimura,Wataru Kimura,Hesham A. Sadek +21 more
TL;DR: It is demonstrated that the endogenous regenerative properties of the adult mammalian heart can be reactivated by exposure to gradual systemic hypoxaemia, and the potential therapeutic role of hypoxia in regenerative medicine is highlighted.
Journal ArticleDOI
Meis1 regulates postnatal cardiomyocyte cell cycle arrest
Ahmed I. Mahmoud,Fatih Kocabas,Shalini Muralidhar,Wataru Kimura,Ahmed Salah Koura,Suwannee Thet,Enzo R. Porrello,Hesham A. Sadek +7 more
TL;DR: It is shown that Meis1 is required for transcriptional activation of the synergistic CDK inhibitors p15, p16 and p21, and is a potential therapeutic target for heart regeneration.
Journal ArticleDOI
Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart
Wataru Kimura,Feng Xiao,Diana C. Canseco,Shalini Muralidhar,Suwannee Thet,Helen M. Zhang,Yezan Abderrahman,Rui Chen,Joseph A. Garcia,John M. Shelton,James A. Richardson,Abdelrahman M. Ashour,Aroumougame Asaithamby,Hanquan Liang,Chao Xing,Zhigang Lu,Cheng Cheng Zhang,Hesham A. Sadek +17 more
TL;DR: F fate mapping of hypoxic cells and their progenies is reported by generating a transgenic mouse expressing a chimaeric protein in which the oxygen-dependent degradation (ODD) domain of Hif-1α is fused to the tamoxifen-inducible CreERT2 recombinase, and indicates that hypoxia signalling is an important hallmark of cycling cardiomyocytes.
Journal ArticleDOI
Erratum: The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response (Cell (2014) 157 (741-743))
Bao N. Puente,Wataru Kimura,Shalini Muralidhar,Jesung Moon,James F. Amatruda,Kate L. Phelps,David Grinsfelder,Beverly A. Rothermel,Rui Chen,Joseph A. Garcia,Celio X.C. Santos,Suwannee Thet,Eiichiro Mori,Michael Kinter,Paul M. Rindler,Serena Zacchigna,Shibani Mukherjee,David J. Chen,Ahmed I. Mahmoud,Mauro Giacca,Peter S. Rabinovitch,Aroumougame Asaithamby,Ajay M. Shah,Luke I. Szweda,Hesham A. Sadek +24 more
TL;DR: This cross-cultural study aimed at determining the carrier and removal status of canine coronavirus in mice shows clear signs of belonging to the “love-hate” group.