K
Katherine Woods
Researcher at Medical College of Wisconsin
Publications - 51
Citations - 2168
Katherine Woods is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Antigen & Immune system. The author has an hindex of 18, co-authored 45 publications receiving 1450 citations. Previous affiliations of Katherine Woods include Trinity College, Dublin & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Marian L. Burr,Marian L. Burr,Marian L. Burr,Christina E. Sparbier,Yih-Chih Chan,James C Williamson,Katherine Woods,Paul A. Beavis,Paul A. Beavis,Enid Y.N. Lam,Enid Y.N. Lam,Melissa A. Henderson,Melissa A. Henderson,Charles C. Bell,Charles C. Bell,Sabine Stolzenburg,Omer Gilan,Omer Gilan,Stuart Bloor,Tahereh Noori,David W. Morgens,Michael C. Bassik,Paul J Neeson,Paul J Neeson,Andreas Behren,Phillip K. Darcy,Phillip K. Darcy,Sarah-Jane Dawson,Sarah-Jane Dawson,Ilia Voskoboinik,Ilia Voskoboinik,Joseph A. Trapani,Joseph A. Trapani,Jonathan Cebon,Paul J. Lehner,Mark A. Dawson +35 more
TL;DR: Insight is provided into the biology of PD-L1 regulation, a previously unrecognized master regulator of this critical immune checkpoint is identified, and a potential therapeutic target to overcome immune evasion by tumour cells is highlighted.
Journal ArticleDOI
Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells.
Marc Rigau,Marc Rigau,Simone Ostrouska,Thomas S Fulford,Darryl N. Johnson,Katherine Woods,Katherine Woods,Zheng Ruan,Hamish E G McWilliam,Chris Hudson,Candani Tutuka,Adam K. Wheatley,Stephen J. Kent,Jose A Villadangos,Bhupinder Pal,Christian Kurts,Jason Simmonds,Matthias Pelzing,Andrew D. Nash,Andrew Hammet,Anne M Verhagen,Gino Vairo,Eugene Maraskovsky,Con Panousis,Nicholas A Gherardin,Jonathan Cebon,Dale I. Godfrey,Andreas Behren,Adam P Uldrich +28 more
TL;DR: A multipronged approach was undertaken to investigate which molecules are necessary for pAg detection by Vγ9Vδ2 T cells and the top candidate molecule identified in the genome-wide screen was butyrophilin 2A1 (BTN2A1), a molecule distinct from, but related to, BTN3A1.
Journal Article
Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine.
TL;DR: The formation and the persistence of H PMPC phosphates in cells and the selective inhibition of viral DNA polymerases by HPMPC diphosphate can explain why cells pretreated with HPM PCs remain refractory to viral infection even long after HPM PC is removed from the medium.
Journal ArticleDOI
The Search for Novel Human Pancreatic α‐Amylase Inhibitors: High‐Throughput Screening of Terrestrial and Marine Natural Product Extracts
Chris A. Tarling,Katherine Woods,Ran Zhang,Harry C. Brastianos,Gary D. Brayer,Raymond J. Andersen,Stephen G. Withers +6 more
TL;DR: A family of three glycosylated acyl flavonols, montbretins A–C, was thereby identified and characterized as competitive amylase inhibitors, with Ki values ranging from 8.1–6100 nM, which suggest a binding mode for these inhibitors.
Journal ArticleDOI
MEK Inhibition, Alone or in Combination with BRAF Inhibition, Affects Multiple Functions of Isolated Normal Human Lymphocytes and Dendritic Cells
Laura J Vella,Anupama Pasam,Nektaria Dimopoulos,Miles C. Andrews,Ashley Knights,Anne Laure Puaux,Jamila Louahed,Weisan Chen,Katherine Woods,Jonathan Cebon +9 more
TL;DR: It is demonstrated that MEK inhibition, alone or in combination with BRAF inhibition, can modulate immune cell function, and further studies in vivo will be required to evaluate the potential clinical impact of these findings.