P
Paul J Neeson
Researcher at Peter MacCallum Cancer Centre
Publications - 158
Citations - 5705
Paul J Neeson is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: T cell & Immunotherapy. The author has an hindex of 31, co-authored 132 publications receiving 3944 citations. Previous affiliations of Paul J Neeson include Royal Melbourne Hospital & University of Melbourne.
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Journal ArticleDOI
Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis
Peter Savas,Balaji Virassamy,Chengzhong Ye,Agus Salim,Agus Salim,Christopher P. Mintoff,Franco Caramia,Roberto Salgado,David J Byrne,Zhi Ling Teo,Zhi Ling Teo,Sathana Dushyanthen,Ann Byrne,Lironne Wein,Stephen J Luen,Catherine Poliness,Sophie Nightingale,Anita S Skandarajah,Anita S Skandarajah,David E. Gyorki,Chantel M Thornton,Paul A. Beavis,Paul A. Beavis,Stephen B. Fox,Phillip K. Darcy,Phillip K. Darcy,Terence P. Speed,Terence P. Speed,Laura K. Mackay,Paul J Neeson,Paul J Neeson,Sherene Loi,Sherene Loi +32 more
TL;DR: Detailed, high-dimensional characterization of T cells in breast cancer reveals activated TRM population and a gene signature associated with improved prognosis and suggest that CD8+ TRM cells contribute to BC immunosurveillance and are the key targets of modulation by immune checkpoint inhibition.
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CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity
Marian L. Burr,Marian L. Burr,Marian L. Burr,Christina E. Sparbier,Yih-Chih Chan,James C Williamson,Katherine Woods,Paul A. Beavis,Paul A. Beavis,Enid Y.N. Lam,Enid Y.N. Lam,Melissa A. Henderson,Melissa A. Henderson,Charles C. Bell,Charles C. Bell,Sabine Stolzenburg,Omer Gilan,Omer Gilan,Stuart Bloor,Tahereh Noori,David W. Morgens,Michael C. Bassik,Paul J Neeson,Paul J Neeson,Andreas Behren,Phillip K. Darcy,Phillip K. Darcy,Sarah-Jane Dawson,Sarah-Jane Dawson,Ilia Voskoboinik,Ilia Voskoboinik,Joseph A. Trapani,Joseph A. Trapani,Jonathan Cebon,Paul J. Lehner,Mark A. Dawson +35 more
TL;DR: Insight is provided into the biology of PD-L1 regulation, a previously unrecognized master regulator of this critical immune checkpoint is identified, and a potential therapeutic target to overcome immune evasion by tumour cells is highlighted.
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Mechanism of action of immunomodulatory drugs (IMiDS) in multiple myeloma
Hang Quach,David Ritchie,David Ritchie,Alexander Keith Stewart,Paul J Neeson,Simon J. Harrison,Mark J. Smyth,Henry Miles Prince,Henry Miles Prince +8 more
TL;DR: Based on in vitro data, it appears that anti-proliferative effects and downregulation of crucial cytokines are their most important anti-MM attributes.
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Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia.
David Ritchie,Paul J Neeson,Paul J Neeson,Amit Khot,Stefan Peinert,Tsin Yee Tai,Kellie M. Tainton,Karen Chen,Mandy Shin,Dominic M. Wall,Dominic M. Wall,Dirk Hönemann,Peter Gambell,David Westerman,Javier Haurat,Jennifer A. Westwood,Jennifer A. Westwood,Andrew M. Scott,Lucy Kravets,Michael Dickinson,Joseph A. Trapani,Joseph A. Trapani,Mark J. Smyth,Mark J. Smyth,Phillip K. Darcy,Phillip K. Darcy,Michael H. Kershaw,Michael H. Kershaw,H. Miles Prince +28 more
TL;DR: This study supports the feasibility and safety of CAR-T-cell therapy in high-risk AML, and demonstrates durable in vivo persistence of CAR T cells.
Journal ArticleDOI
Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity.
Alex Davenport,Ryan S. Cross,Ryan S. Cross,Kimberly A. Watson,Yang Liao,Wei Shi,Henry Miles Prince,Paul A. Beavis,Joseph A. Trapani,Michael H. Kershaw,David Ritchie,Phillip K. Darcy,Paul J Neeson,Misty R. Jenkins +13 more
TL;DR: A mechanism for how CAR-T cells can debulk large tumor burden quickly is provided and may contribute to further refinement of CAR design for enhancing the quality of signaling and programming of the T cell.