K
Kathleen C. Woulfe
Researcher at Anschutz Medical Campus
Publications - 40
Citations - 1950
Kathleen C. Woulfe is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 29 publications receiving 1631 citations. Previous affiliations of Kathleen C. Woulfe include University of Colorado Boulder & Thomas Jefferson University.
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Journal ArticleDOI
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
Tammy F. Chu,Tammy F. Chu,Maria Rupnick,Maria Rupnick,Risto Kerkelä,Susan M. Dallabrida,David Zurakowski,Lisa Nguyen,Kathleen C. Woulfe,Elke Pravda,Flavia Cassiola,Jayesh Desai,Suzanne George,David M. Harris,Nesreen S. Ismail,Jey-Hsin Chen,Frederick J. Schoen,Annick D. Van den Abbeele,George D. Demetri,Thomas Force,Ming-Hui Chen,Ming-Hui Chen,Jeffrey A. Morgan +22 more
TL;DR: Left ventricular dysfunction might be due, in part, to direct cardiomyocyte toxicity, exacerbated by hypertension, and patients treated with sunitinib should be closely monitored for hypertension and LVEF reduction, especially those with a history of coronary artery disease or cardiac risk factors.
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Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation
Risto Kerkelä,Lisa Kockeritz,Katrina MacAulay,Jibin Zhou,Bradley W. Doble,Cara Beahm,Sarah Greytak,Kathleen C. Woulfe,Chinmay M. Trivedi,James R. Woodgett,Jonathan A. Epstein,Thomas Force,Gordon S. Huggins +12 more
TL;DR: These studies, which are believed to be the first in mammals to examine the role of GSK-3alpha and Gsk-3beta in the heart using loss-of-function approaches, implicate GSK -3beta as a central regulator of embryonic cardiomyocyte proliferation and differentiation, as well as of outflow tract development.
Journal ArticleDOI
Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase
Risto Kerkelä,Kathleen C. Woulfe,Jean-Bernard Durand,Ronald J. Vagnozzi,David Kramer,Tammy F. Chu,Tammy F. Chu,Cara Beahm,Ming-Hui Chen,Ming-Hui Chen,Thomas Force +10 more
TL;DR: It is found that adenovirus‐mediated gene transfer of an activated mutant of AMPK reduces sunitinib‐induced cell death, suggesting AMPK inhibition plays a central role in sunit inib cardiomyocyte toxicity, highlighting the potential of off‐target effects of TKIs contributing to cardiotoxicity.
Journal ArticleDOI
Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo
Kathleen C. Woulfe,Erhe Gao,Hind Lal,David M. Harris,Qian Fan,Ronald J. Vagnozzi,Morgan DeCaul,Xiying Shang,Satish Patel,James R. Woodgett,Thomas Force,Jibin Zhou +11 more
TL;DR: It is suggested that inhibition of GSK-3&bgr; could be a strategy to both prevent remodeling and to promote cardiac regeneration in pathological states.
Journal ArticleDOI
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
Joshua G. Travers,Sara A. Wennersten,Brisa Peña,Rushita A. Bagchi,Harrison E. Smith,Harrison E. Smith,Rachel A. Hirsch,Lauren A. Vanderlinden,Ying-Hsi Lin,Evgenia Dobrinskikh,Kimberly M. Demos-Davies,Maria A. Cavasin,Luisa Mestroni,Christian Steinkühler,Charles Y. Lin,Steven R. Houser,Kathleen C. Woulfe,Maggie P.Y. Lam,Timothy A. McKinsey +18 more
TL;DR: In this paper, the authors showed that diastolic dysfunction is associated with the development of heart failure and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation.