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Steven R. Houser
Researcher at Temple University
Publications - 292
Citations - 17147
Steven R. Houser is an academic researcher from Temple University. The author has contributed to research in topics: Heart failure & Myocyte. The author has an hindex of 71, co-authored 274 publications receiving 15151 citations. Previous affiliations of Steven R. Houser include National Institutes of Health & Drexel University.
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Journal ArticleDOI
A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle
Benjamin R. Nelson,Catherine A. Makarewich,Douglas M. Anderson,Benjamin R. Winders,Constantine D Troupes,Fenfen Wu,Austin L Reese,John R. McAnally,Xiongwen Chen,Ege T. Kavalali,Stephen C. Cannon,Steven R. Houser,Rhonda Bassel-Duby,Eric N. Olson +13 more
TL;DR: Dwarf open reading frame (DWORF) is the only endogenous peptide known to activate the SERCA pump by physical interaction and provides a means for enhancing muscle contractility.
Journal ArticleDOI
Embryonic Stem Cell-Derived Exosomes Promote Endogenous Repair Mechanisms and Enhance Cardiac Function Following Myocardial Infarction
Mohsin Khan,Emily Nickoloff,Tatiana Abramova,Jennifer M. Johnson,Suresh K Verma,Prasanna Krishnamurthy,Alexander R Mackie,Erin E Vaughan,Venkata Naga Srikanth Garikipati,Cindy Benedict,Veronica Ramirez,Erin Lambers,Aiko Ito,Erhe Gao,Sol Misener,Timothy S. Luongo,John W. Elrod,Gangjian Qin,Steven R. Houser,Walter J. Koch,Raj Kishore +20 more
TL;DR: It is demonstrated that mouse ESC-derived exosomes (mES Ex) possess ability to augment function in infarcted hearts and provide a novel cell-free system that uses the immense regenerative power of ES cells while avoiding the risks associated with direct ES or ES-derived cell transplantation and risk of teratomas.
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Cellular Basis of Abnormal Calcium Transients of Failing Human Ventricular Myocytes
Valentino Piacentino,Christopher R. Weber,Xiongwen Chen,Jutta Weisser-Thomas,Kenneth B. Margulies,Donald M. Bers,Steven R. Houser +6 more
TL;DR: Changes in the respective roles of the L-type Ca2+ current, SR Ca 2+ uptake, storage and release, Ca2+, transport via the Na+-Ca2+ exchanger (NCX), and Ca2- buffering in the altered Ca2 + transients of failing human ventricular myocytes can explain the defective Ca2+.
Journal ArticleDOI
Myocyte Recovery After Mechanical Circulatory Support in Humans With End-Stage Heart Failure
Konstantina Dipla,Julian A. Mattiello,Valluvan Jeevanandam,Steven R. Houser,Kenneth B. Margulies +4 more
TL;DR: The results of the study strongly support the idea that circulatory support with an LVAD improves myocyte contractile properties and increases beta-adrenergic responsiveness.
Journal ArticleDOI
Animal Models of Heart Failure A Scientific Statement From the American Heart Association
Steven R. Houser,Kenneth B. Margulies,Anne M. Murphy,Francis G. Spinale,Gary S. Francis,Sumanth D. Prabhu,Howard A. Rockman,David A. Kass,Jeffery D. Molkentin,Mark A. Sussman,Walter J. Koch +10 more
TL;DR: The distinctive clinical features of the major causes of HF in humans are defined and those distinctive pathological features ofHF in humans that should be present in an animal model being used to identify fundamental causes ofHF or to test preventative or reparative therapies that could reduce HF morbidity and mortality are recommended.