Kathleen F. Nolan

TL;DR: It is shown that antigen-specific Tregs induce, within skin grafts and dendritic cells, the expression of enzymes that consume at least 5 different essential amino acids (EAAs), and that T cells fail to proliferate in response to antigen when any 1, or more, of these EAAs are limiting.

TL;DR: It is shown that CD73 expression on activated murine CD4+ T cells is induced by TGF‐β independently of Foxp3 expression, operates at the transcriptional level and translates into gain of functional capacity to generate adenosine, exposing a novel anti‐inflammatory role for T GF‐β.

TL;DR: It was found that independently derived, regulatory Tr1‐like clones were highly concordant in their patterns of gene expression but were quite distinct from CD4+CD25+ regulatory T cells from the spleen.

TL;DR: This review considers the interplay between Tregs, dendritic cells, and the graft itself and the resulting local protective mechanisms that are coordinated to maintain the tolerant state and the induction of local immune privilege has implications for the design of therapeutic regimens and the monitoring of the tolerant status of patients being weaned off immunosuppression.

TL;DR: A method for the prevention or treatment of a condition selected from type 2 diabetes, obesity and metabolic syndrome comprising activating a GITRL pathway was proposed in this paper, which is a method for screening for substances to treat these conditions, diagnosing or predicting these conditions and selecting and monitoring therapies.