Nathan J. Robertson

TL;DR: It is shown that even expression of minor histocompatibility (mH) antigens is sufficient to provoke acute rejection of tissues differentiated from ES cells, suggesting the natural privileged status of ES cell-derived tissues may be harnessed effectively for the induction of dominant tolerance with minimal therapeutic intervention.

TL;DR: This review considers the interplay between Tregs, dendritic cells, and the graft itself and the resulting local protective mechanisms that are coordinated to maintain the tolerant state and the induction of local immune privilege has implications for the design of therapeutic regimens and the monitoring of the tolerant status of patients being weaned off immunosuppression.

TL;DR: While the dust begins to settle, it is perhaps pertinent to ask whether the promise of SNT is still worth pursuing or whether alternative strategies for immune evasion might help fill the void.

TL;DR: The subcapsular region of the kidney has frequently served as the site of choice for transplantation studies owing to a number of compelling reasons, and transplantation to this site has proven important for studies of both central and peripheral tolerance.

TL;DR: The extent of the immunological barriers encountered and the potential of different approaches to overcoming these issues are explored, of which somatic nuclear transfer (SNT) and the induction of transplanation tolerance are currently the most promising.