David R. Greaves

TL;DR: The structure, biochemical features, tissue distribution and chromosomal localization of CX3C chemokine all indicate that it represents a unique class of chemokines that may constitute part of the molecular control of leukocyte traffic at the endothelium.

TL;DR: The results indicate that the DNA regions flanking the human beta-globin locus contain dominant regulatory sequences that specify position-independent expression and normally activate the complete human multigene beta- globin loci.

TL;DR: In this paper, the authors show that in response to interleukin-4 (IL-4), signal transducer and activator of transcription 6 (STAT6) and PPARgamma-coactivator-1beta (PGC-1β) induce macrophage programs for fatty acid oxidation and mitochondrial biogenesis, suggesting a potential role for metabolic therapies in treating atherogenic inflammation.

TL;DR: The identification of TACE as a major protease responsible for the conversion of fractalkine from a membrane-bound adhesion molecule to a soluble chemoattractant will provide new information for understanding the physiological function of this chemokine.

TL;DR: This work analyzes and compares the transcriptome and proteome of human and murine macrophages under resting conditions (M0) and after IL-4 activation (M2) and provides a resource for tools enabling macrophage detection in human tissues by identifying a set of 87 Macrophage-related genes.