Kathleen K. Bierilo

TL;DR: The availability of both the cloned human B1 and B2 bradykinin receptors should allow the elucidation of the relative contributions of these two receptor subtypes in acute and chronic inflammatory processes.

TL;DR: The biochemical characterization of anacetrapib, a potent inhibitor of CETP, was described and dalcetrapib was found to covalently label both human and mouse plasma proteins, indicating that these inhibitors promote the formation of a complex between CETP and HDL, resulting in inhibition of CETp activity.

TL;DR: It is suggested that while PCSK9 plays an important role in regulating circulating LDL cholesterol levels by reducing the number of hepatic LDLRs, it does not appear to modulate the levels of LDLR and other membrane-bound proteins in the adult mouse brain.

TL;DR: A rabbit B1 bradykinin receptor cDNA was isolated from a rabbit aorta smooth muscle cell library and exhibits the classical B1 pharmacological property of preferentially binding to kinin analogues which lack the C-terminal arginine.

TL;DR: This assay is capable of supporting cardiovascular research by providing a single assay to measure critical biomarkers across multiple species without the need for antibodies, and does so in a high-throughput manner.