K
Kathryn Kehoe
Researcher at Mayo Clinic
Publications - 3
Citations - 1252
Kathryn Kehoe is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Ubiquitin ligase & Proteasome. The author has an hindex of 3, co-authored 3 publications receiving 1178 citations.
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Journal ArticleDOI
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
Leonard Petrucelli,Dennis W. Dickson,Kathryn Kehoe,Julie P. Taylor,Heather Snyder,Andrew Grover,Michael De Lucia,Eileen McGowan,Jada Lewis,G. Prihar,Jungsu Kim,Wolfgang H. Dillmann,Susan E. Browne,Alexis Hall,Richard Voellmy,Yoshio Tsuboi,Ted M. Dawson,Benjamin Wolozin,John Hardy,Mike Hutton +19 more
TL;DR: It is reported that CHIP, an ubiquitin ligase that interacts directly with Hsp70/90, induces ubiquitination of the microtubule associated protein, tau, and that diverse of tau lesions in human postmortem tissue were found to be immunopositive for CHIP.
Journal ArticleDOI
Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons.
Leonard Petrucelli,Casey O'Farrell,Paul J. Lockhart,Melisa J. Baptista,Kathryn Kehoe,Liselot Vink,Peter Choi,Benjamin Wolozin,Matthew J. Farrer,John Hardy,Mark R. Cookson +10 more
TL;DR: Parkin is capable of rescuing the toxic effects of mutant alpha-synuclein or proteasome inhibition in these cells, and parkin and alpha- synuclein are linked by common effects on a pathway associated with selective cell death in catecholaminergic neurons.
Journal ArticleDOI
P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation
Leonard Petrucelli,Julie P. Taylor,Kathryn Kehoe,Jada Lewis,Eileen McGowan,Heather Snyder,Ben Wolozin,Ted M. Dawson,Wolfgang H. Dillmann,Richard Voellmy,Mike Hutton +10 more
TL;DR: It is reported that CHIP, an ubiquitin ligase that interacts directly with Hsp70/90, induces ubiquitination of the microtubule associated protein, tau, and that diverse of tau lesions in human postmortem tissue were found to be immunopositive for CHIP.