K
Kati Karell
Researcher at Finnish Red Cross
Publications - 9
Citations - 885
Kati Karell is an academic researcher from Finnish Red Cross. The author has contributed to research in topics: Haplotype & Human leukocyte antigen. The author has an hindex of 9, co-authored 9 publications receiving 846 citations.
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Journal ArticleDOI
Hla types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the european genetics cluster on celiac disease
Kati Karell,A.S. Louka,S J Moodie,Henry Ascher,F. Clot,Luigi Greco,Paul J. Ciclitira,Ludvig M. Sollid,Jukka Partanen +8 more
TL;DR: The results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the D Q2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone.
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Concordance of Dermatitis Herpetiformis and Celiac Disease in Monozygous Twins
TL;DR: Genetically identical individuals can have clearly distinguished phenotypes, either dermatitis herpetiformis or celiac disease, suggesting that environmental factors determine the exact phenotype of this multifactorial disease.
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Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations
Lotta L. E. Koskinen,Jihane Romanos,Katri Kaukinen,K. Mustalahti,Ilma Rita Korponay-Szabó,Ilma Rita Korponay-Szabó,Donatella Barisani,Maria Teresa Bardella,Fabiana Ziberna,Serena Vatta,György Széles,Zsuzsa Pocsai,Kati Karell,Katri Haimila,Róza Ádány,Tarcisio Not,Alessandro Ventura,Markku Mäki,Jukka Partanen,Cisca Wijmenga,Päivi Saavalainen +20 more
TL;DR: Using the tagging SNP method, it is possible to determine the celiac disease risk haplotypes accurately in Finnish, Hungarian, and Italian populations, with specificity and sensitivity ranging from 95% to 100%.
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Additional factor in some HLA DR3/DQ2 haplotypes confers a fourfold increased genetic risk of celiac disease.
Elisabetta Bolognesi,Kati Karell,S. Percopo,Iolanda Coto,Luigi Greco,V. Mantovani,E. Suoraniemi,Jukka Partanen,K. Mustalahti,Markku Mäki,Patricia Momigliano-Richiardi +10 more
TL;DR: While DQ2 is an absolute requirement for the development of CD, the presence of an additional genetic factor within the MIC-Class I region confers an approximate 4-fold increased risk of the disease.
Journal ArticleDOI
Genetic dissection between coeliac disease and dermatitis herpetiformis in sib pairs
Kati Karell,Ilma Rita Korponay-Szabó,Zsuzsanna Szalai,P. Holopainen,K. Mustalahti,Pekka Collin,Markku Mäki,Jukka Partanen +7 more
TL;DR: Results from the Finnish family material with 25 discordant and 85 concordant sib pairs, and from additional case-control material comprising 71 unrelated Hungarian DH and 68 cCD patients, together indicated that the HLA DQ locus did not differ between the two major outcomes of gluten sensitive enteropathy.