Showing papers by "Kavita Shah published in 2010"
TL;DR: Indolyl-1,3,4-thiadiazole 5m with 4-benzyloxy-3-methoxyphenyl and 5-bromo indolyl substituents is the most active in suppressing the growth of cancer cells.
163 citations
TL;DR: Wang et al. as discussed by the authors showed that deregulated cyclin-dependent kinase (Cdk) 5 induces p38 activation by increasing reactive oxygen species (ROS) in neuronal cells and in primary cortical neurons.
Abstract: Cyclin-dependent kinase (Cdk) 5 and p38 activities are significantly increased in Alzheimer's Disease (AD). Both p38 and Cdk5 promote neurodegeneration upon deregulation. However, to date the mechanistic link between Cdk5 and p38 remains unclear. This study presents the first mechanism showing Cdk5 as a major regulator of p38 cascade in neurons and in transgenic mouse model of AD. Using beta-amyloid and glutamate as the neurotoxic stimuli, our results show that deregulated Cdk5 induces p38 activation by increasing reactive oxygen species (ROS) in neuronal cells and in primary cortical neurons. Elimination of ROS inhibits p38 activation, revealing ROS as major stimuli of the p38 cascade. Importantly, Cdk5-mediated p38 activation increases c-Jun expression, thereby revealing a mechanistic link between deregulated Cdk5 and c-Jun level in AD brains. c-Jun is over-expressed in AD, and is believed to contribute significantly to neurodegeneration. Based on the proposed mechanism, Cdk5 inhibition is more neuroprotective relative to p38 and c-Jun, suggesting that Cdk5 is an upstream regulator of neurodegenerative pathways triggered by p38 and a preferable therapeutic target for AD.
64 citations
TL;DR: The 4-(3'-indolyl)oxazoles 5d and 11 were found to be most cytotoxic and selective against various cancer cell lines and showed moderate anticancer activity.
57 citations
TL;DR: Using the techniques of magnetization, resistivity, and specific heat, this article showed evidence of strong electron correlations in orthorhombic R2Ru3Ga9 (R=Ce and U).
Abstract: Using the techniques of magnetization, resistivity, and specific heat, we show evidence of strong electron correlations in orthorhombic R2Ru3Ga9 (R=Ce and U). U2Ru3Ga9 orders antiferromagnetically with TN=16.5 K, while the Ce analog shows Pauli paramagnetic, mixed valence behavior with a linear coefficient of the electronic heat capacity ∼250 mJ/mol K2. Their resistivity increases with decreasing temperature below 300 K, showing broad peaks in the ∼60–80 K range. Reduced effective paramagnetic moment and magnetic entropy suggest a low-moment state of uranium ions in U2Ru3Ga9 arising due to 5f-conduction electron hybridization. Simultaneously, the heat capacity data indicate an enhanced electronic heat capacity coefficient comparable to that of Ce2Ru3Ga9.
4 citations
2 citations
TL;DR: A series of 4-(3′-indolyl)oxazole congeners have been synthesized and studied for their cytotoxicity against six cancer cell lines as mentioned in this paper.
Abstract: A series of 4-(3′-indolyl)oxazole congeners have been synthesized and studied for their cytotoxicity against six cancer cell lines. Reaction of 3-acetyl-1′-benzenesulfonylindole with [hydroxy(tosyloxy)iodo]benzene afforded pure 3-tosyloxyacetyl-1′-benzenesulfonylindole. Microwave-accelerated neat reaction of 3-tosyloxyacetyl-1-benzenesulfonylindole with amides resulted in the exclusive formation of 4-(1′-benzenesulfonylindol-3′-yl)-2-substituted oxazoles (4) in very good yield. Treatment of 4 with aqueous sodium hydroxide under refluxing conditions afforded pure 4-(3′-indolyl)-2-substituted oxazoles (5) in excellent yield. The 4-(3′-indolyl)oxazoles 5d and 11 were found to be most cytotoxic and selective against various cancer cell lines. Compounds 5g, 5j and 5l showed moderate anticancer activity.
2 citations