K
Kayan M. Parker
Researcher at University of Sheffield
Publications - 2
Citations - 4589
Kayan M. Parker is an academic researcher from University of Sheffield. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 2, co-authored 2 publications receiving 4021 citations.
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Journal ArticleDOI
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant,Nilklas Schultz,Huw D. Thomas,Kayan M. Parker,Dan Flower,Elena Lopez,Suzanne Kyle,Mark Meuth,Nicola J. Curtin,Thomas Helleday,Thomas Helleday +10 more
TL;DR: It is proposed that, in the absence of PARP1, spontaneous single-strand breaks collapse replication forks and trigger homologous recombination for repair and exploited in order to kill BRCA2-deficient tumours by PARP inhibition alone.
Journal ArticleDOI
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Nasrollah Saleh-Gohari,Helen E. Bryant,Niklas Schultz,Kayan M. Parker,Tobias N. Cassel,Tobias N. Cassel,Thomas Helleday,Thomas Helleday +7 more
TL;DR: It is suggested that a first homologous recombination event frequently triggers a second event at the same locus in mammalian cells.