K
Kazuhiko Fukui
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 84
Citations - 1238
Kazuhiko Fukui is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Binding site & Polymer. The author has an hindex of 20, co-authored 81 publications receiving 1037 citations. Previous affiliations of Kazuhiko Fukui include Oak Ridge National Laboratory.
Papers
More filters
Journal ArticleDOI
CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy
Hiroshi Kagamu,Shigehisa Kitano,Ou Yamaguchi,Kennichi Yoshimura,Katsuhisa Horimoto,Masashi Kitazawa,Kazuhiko Fukui,Ayako Shiono,Atsuhito Mouri,Fuyumi Nishihara,Yu Miura,Kosuke Hashimoto,Yoshitake Murayama,Kyoichi Kaira,Kunihiko Kobayashi +14 more
TL;DR: Low numbers of circulating CD62lowCD4+ T cells positively correlate with responsiveness of NSCLC patients to PD-1 blockade, and a formula, which demonstrated 85.7% sensitivity and 100% specificity, based on the percentages of CD62Llow CD4-cell T cells and CD25+FOXP3+ cells to predict nonresponders is developed.
Journal ArticleDOI
A large-scale targeted proteomics assay resource based on an in vitro human proteome
Masaki Matsumoto,Fumiko Matsuzaki,Kiyotaka Oshikawa,Naoki Goshima,Masatoshi Mori,Yoshifumi Kawamura,Koji Ogawa,Eriko Fukuda,Hirokazu Nakatsumi,Tohru Natsume,Kazuhiko Fukui,Katsuhisa Horimoto,Takeshi Nagashima,Ryo Funayama,Keiko Nakayama,Keiichi I. Nakayama +15 more
TL;DR: A targeted proteomics platform—in vitro proteome–assisted multiple reaction monitoring (MRM) for proteinabsolute quantification (iMPAQT) by using >18,000 human recombinant proteins, thus enabling protein absolute quantification on a genome-wide scale.
Journal ArticleDOI
Redox Sensitivities of Global Cellular Cysteine Residues under Reductive and Oxidative Stress
Kazutaka Araki,Hidewo Kusano,Naoyuki Sasaki,Riko Tanaka,Tomohisa Hatta,Kazuhiko Fukui,Tohru Natsume +6 more
TL;DR: Quantitative data illustrated both H2O2- and reduction-mediated cellular responses, whereby while redox homeostasis is maintained, highly reactive thiols can potentiate the specific, rapid cellular signaling to counteract acute redox stress.
Journal ArticleDOI
Analysis of glycosyl bond cleavage and related isotope effects in collision-induced dissociation quadrupole-time-of-flight mass spectrometry of isomeric trehaloses.
TL;DR: The isotope effect regarding beta, beta-trehalose is larger than those of alpha,alpha- and alpha,beta-Trehalose, indicating that the isotope effects on the beta-glycosyl bond cleavage is largerthan that on the alpha-glyCosyl Bond cleavage.
Journal ArticleDOI
Probing Phase-Separation Behavior in Polymer-Blend Microparticles: Effects of Particle Size and Polymer Mobility
TL;DR: In this paper, the phase separation behavior of polymer-blend systems in spherical microparticles generated from microdroplets of dilute polymer solution is investigated using two-dimensional optical diffractiona technique.