S
Shigehisa Kitano
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 122
Citations - 4724
Shigehisa Kitano is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 26, co-authored 85 publications receiving 3860 citations. Previous affiliations of Shigehisa Kitano include Saitama Medical University & Mie University.
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Journal ArticleDOI
Immunologic Correlates of the Abscopal Effect in a Patient with Melanoma
Michael A. Postow,Margaret K. Callahan,Margaret K. Callahan,Christopher A. Barker,Christopher A. Barker,Yoshiya Yamada,Yoshiya Yamada,Jianda Yuan,Shigehisa Kitano,Zhenyu Mu,Teresa S. Rasalan,Matthew Adamow,Erika Ritter,Christine Sedrak,Achim A. Jungbluth,Ramon Chua,Arvin Yang,Ruth Ann Roman,Samuel Rosner,Brenna Benson,James P. Allison,Alexander M. Lesokhin,Alexander M. Lesokhin,Sacha Gnjatic,Jedd D. Wolchok,Jedd D. Wolchok,Jedd D. Wolchok +26 more
TL;DR: A case of the abscopal effect is reported in a patient with melanoma treated with ipilimumab and radiotherapy, with temporal associations of tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibodies to other antigens after radiotherapy.
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Monocytic CCR2+ Myeloid Derived Suppressor Cells Promote Immune Escape By Limiting Activated CD8 T Cell Infiltration Into The Tumor Microenvironment
Alexander M. Lesokhin,Tobias M. Hohl,Shigehisa Kitano,Czrina Cortez,Daniel Hirschhorn-Cymerman,Francesca Avogadri,Gabrielle Rizzuto,John J. Lazarus,Eric G. Pamer,Alan N. Houghton,Taha Merghoub,Jedd D. Wolchok +11 more
TL;DR: It is shown that granulocyte-macrophage colony stimulating factor, a cytokine critical for the numeric and functional development of MDSC populations, promotes expansion of a monocyte-derived MDSCs population characterized by expression of CD11b and the chemokine receptor CCR2.
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Metabolic activity by 18 F–FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC
Kyoichi Kaira,Tetsuya Higuchi,Ichiro Naruse,Yukiko Arisaka,Azusa Tokue,Bolag Altan,Satoshi Suda,Akira Mogi,Kimihiro Shimizu,Noriaki Sunaga,Takeshi Hisada,Shigehisa Kitano,Hideru Obinata,Takehiko Yokobori,Keita Mori,Masahiko Nishiyama,Yoshihito Tsushima,Takayuki Asao +17 more
TL;DR: Metabolic response by 18F–FDG was effective in predicting efficacy and survival at 1 month after nivolumab treatment and Multivariate analysis confirmed that 18F-FDG uptake after administration of nivlumab was an independent prognostic factor.
Journal ArticleDOI
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
Daniel Hirschhorn-Cymerman,Sadna Budhu,Shigehisa Kitano,Cailian Liu,Feng Zhao,Hong Zhong,Alexander M. Lesokhin,Alexander M. Lesokhin,Francesca Avogadri-Connors,Jianda Yuan,Yanyun Li,Alan N. Houghton,Alan N. Houghton,Taha Merghoub,Jedd D. Wolchok +14 more
TL;DR: This data indicates thatOX40 engagement induces a cytotoxic CD4+ T cell subpopulation to eradicate advance melanomas and this work is likely to be a game-changer in the fight against advanced melanomas.
Journal ArticleDOI
CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy
Hiroshi Kagamu,Shigehisa Kitano,Ou Yamaguchi,Kennichi Yoshimura,Katsuhisa Horimoto,Masashi Kitazawa,Kazuhiko Fukui,Ayako Shiono,Atsuhito Mouri,Fuyumi Nishihara,Yu Miura,Kosuke Hashimoto,Yoshitake Murayama,Kyoichi Kaira,Kunihiko Kobayashi +14 more
TL;DR: Low numbers of circulating CD62lowCD4+ T cells positively correlate with responsiveness of NSCLC patients to PD-1 blockade, and a formula, which demonstrated 85.7% sensitivity and 100% specificity, based on the percentages of CD62Llow CD4-cell T cells and CD25+FOXP3+ cells to predict nonresponders is developed.