Kazuo Nishigaki

TL;DR: Results indicated that FIV might not play a direct role in tumorigenesis of lymphoma in cats and that no consistent tumor type was found in lymphoma cases infected with FIV.

TL;DR: Long terminal repeats of feline leukemia viruses cloned from feline acute myeloid leukemias frequently contained direct repeats of 40 to 74 bp in the upstream region of the enhancer (URE), suggesting its association with tumorigenic potential in myeloids cells.

TL;DR: Findings indicated that feline GL tumors can be considered as a specific disease entity in feline lymphomas because the cases examined in this study showed onset at an older age, a low incidence of FeLV infection and frequent involvement of gastrointestinal lesions, which are not found in typical FeLV-associated lymphomas.

TL;DR: RT-PCR/SSCP (single strand conformation polymorphism) analysis of p27Kip1 cDNA did not uncover any amino acid substitutions in the 10 feline leukemia and lymphoma cases that were examined, andSouthern-blot analyses of 17 feline spontaneous leukemia andymphoma cases using these cDNAs as probes did not reveal any rearrangements in either the p21WAF1 or the p27kip1 gene.

TL;DR: The present study revealed the strong promoter activity of the FeLV LTR with 3 enhancer repeats and its modular enhancer elements positively regulating the transcription in a relatively tissue-specific manner.