Ryo Goitsuka

TL;DR: It is shown that FcɛRI stimulation triggers the formation of microtubules in a manner independent of calcium, and that the Fyn/Gab2/RhoA (but not Lyn/SLP-76) signaling pathway plays a critical role in the calcium-independent microtubule-dependent pathway.

TL;DR: A novel gene preferentially expressed in bursal B cells, designated BASH, is suggested to be involved in BCR-mediated signal transduction and could play a critical role in B cell development in the bursa.

TL;DR: Notch1 signaling induces apoptosis of the B cells through Hairy1, and the G1 cell cycle arrest through other pathways, which may account for the recent observations indicating the selective inhibition of early B cell development in mice by Notch1.

TL;DR: It is shown that the intracellular signaling molecule SMAD1, acting downstream of bone morphogenetic protein (BMP) receptors, is required for the commitment of germ cell lineage from epiblast in early mouse embryos.

TL;DR: The BASH-deficient B cells scarcely proliferated or up-regulated B7-2 in response to BCR ligation and poorly proliferated upon CD40 ligation or lipopolysaccharide stimulation, which indicates that BASH is critical for preB cell receptor signaling inducing proliferation of large preB cells and the following differentiation, for peripheral B cell maturation, and for BCR signaling inducing activation/proliferation of B cells.