K
Kazuoki Ohsumi
Researcher at Mitsubishi
Publications - 10
Citations - 482
Kazuoki Ohsumi is an academic researcher from Mitsubishi. The author has contributed to research in topics: Parathyroid hormone-related protein & Endothelins. The author has an hindex of 9, co-authored 10 publications receiving 469 citations.
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Journal ArticleDOI
Increase of vascular endothelial growth factor mRNA expression by 1,25‐dihydroxyvitamin D3 in human osteoblast‐like cells
Da Shen Wang,Kazuko Yamazaki,Kyoko Nohtomi,Kazuo Shizume,Kazuoki Ohsumi,Masabumi Shibuya,Hiroshi Demura,Kanji Sato +7 more
TL;DR: It is demonstrated that PTH, IGF‐I, and most potently 1, 25‐(OH)2D3 stimulate the mRNA expression and secretion of VEGF in human osteoblast‐like cells, suggesting that one of the anabolic effects of 1,25‐ (OH) 2D3 on skeletal tissue may be mediated by V EGF produced by osteoblasts.
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Human Ryudocan from Endothelium-like Cells Binds Basic Fibroblast Growth Factor, Midkine, and Tissue Factor Pathway Inhibitor
Tetsuhito Kojima,Akira Katsumi,Tomio Yamazaki,Takashi Muramatsu,Tetsuro Nagasaka,Kazuoki Ohsumi,Hidehiko Saito +6 more
TL;DR: The findings suggest that ryudocan may possess multiple biological functions, such as bFGF modulation, neurite growth promotion, and anticoagulation, via HS-binding effectors in the cellular microenvironment.
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Passive immunization with anti-parathyroid hormone-related protein monoclonal antibody markedly prolongs survival time of hypercalcemic nude mice bearing transplanted human PTHrP-producing tumors
Kanji Sato,Yukiko Yamakawa,Kazuo Shizume,Tomoko Satoh,Kyoko Nohtomi,Hiroshi Demura,Takuhiko Akatsu,Naokazu Nagata,Tadashi Kasahara,Hiroyuki Ohkawa,Kazuoki Ohsumi +10 more
TL;DR: Results suggest that passive immunization against PTHrP can continuously ameliorate the hypercalcemia and markedly prolong the survival time of severely hypercalcemic, tumor‐bearing mice.
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Plasma immunoreactive endothelin, but not thrombomodulin, is increased in patients with essential hypertension and ischemic heart disease.
Mitsuhide Naruse,Masatoshi Kawana,S Hifumi,Kiyoko Naruse,I Yoshihara,T Oka,Yuko Kato,C Monzen,F Kurimoto,Kazuoki Ohsumi +9 more
TL;DR: The results suggest that ET plays an important role in the pathophysiology of EH and ischemic heart disease, and also that increases in plasma ET cannot be simply attributed to a leakage of the peptide from the injured endothelial cells.
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Is big endothelin converted to endothelin-1 in circulating blood?
Y. Watanabe,Mitsuhide Naruse,C Monzen,Kiyoko Naruse,Kazuoki Ohsumi,Junko Horiuchi,I Yoshihara,Yuko Kato,Noriko Nakamura,M Kato +9 more
TL;DR: Results suggest that circulating blood may not be a major site of molecular conversion from big ET-1 toET-1, although conversion does occur in the circulation by blood cell-mediated process.