T
Takashi Muramatsu
Researcher at Aichi Gakuin University
Publications - 459
Citations - 23809
Takashi Muramatsu is an academic researcher from Aichi Gakuin University. The author has contributed to research in topics: Midkine & Pleiotrophin. The author has an hindex of 84, co-authored 444 publications receiving 22930 citations. Previous affiliations of Takashi Muramatsu include Kagoshima University & Nagoya University.
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cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis.
TL;DR: A cDNA clone was isolated, MK1, whose RNA level increased in early stages of retinoic acid-induced differentiation of embryonal carcinoma cells, and the amount of MK1 RNA progressively decreased in the later stages of the differentiation.
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A Small Interfering RNA Targeting Vascular Endothelial Growth Factor as Cancer Therapeutics
TL;DR: The novel VEGF blockade system using RNA interference with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model and provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.
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Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis
TL;DR: The expression of MK and PTN is increased in various human tumors, making them promising as tumor markers and as targets for tumor therapy, and from the viewpoints of the treatment of neurodegenerative diseases, increasing the efficiency of in vitro development, and the prevention of HIV infection.
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Midkine and pleiotrophin in neural development and cancer
TL;DR: MK and PTN are candidate molecular targets for therapy for human carcinomas because they share receptors, and show similar biological activities that include fibrinolytic, anti-apoptotic, mitogenic, transforming, angiogenic, and chemotactic ones.
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A receptor-like protein-tyrosine phosphatase PTPzeta/RPTPbeta binds a heparin-binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTPzeta.
Nobuaki Maeda,Keiko Ichihara-Tanaka,Terutoshi Kimura,Kenji Kadomatsu,Takashi Muramatsu,Masaharu Noda +5 more
TL;DR: Results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor.