Ke Ding

TL;DR: These findings establish the link between sensing of environmental cues by the external proteins and activation of endogenous RNA transcription by the TEC inside the virus.

TL;DR: In situ cryo-electron microscopy structures of rotavirus dsRNA-dependent RNA polymerase (RdRp) in two states pertaining to transcription are presented, providing insights into the mechanism of viral mRNA transcription by determining the in situ Cryo-EM structures of a working rotav virus’ RNA-dependent-RNA polymerase, which is of interest for antiviral drug design.

TL;DR: The structure of the leishmanial ribosome elucidates the organization of the six fragments of its large subunit rRNA and reveals atomic details of a unique 20 amino acid extension of the uL13 protein that pins down the ends of three of the rRNA fragments.

TL;DR: The authors report near-atomic resolution structures of the R-type bacteriocin from Pseudomonas aeruginosa in the pre-contracted and post-contraction states, and these structures provide insight into the mechanism of action of molecular syringes.

TL;DR: The structural changes of RdRp VP1 and associated capsid shell proteins between BTV virions and cores suggest that the detachment of the outer capsid proteins VP2 and VP5 during viral entry induces both global movements of the inner Capsid shell and local conformational changes of the N-terminal latch helix.