Ke-feng Ren

TL;DR: Recent work on designing and controlling film properties at the nanometer and micrometer scales with a view to developing new biomaterial coatings, tissue engineered constructs that could mimic in vivo cellular microenvironments, and stem cell “niches” is highlighted.

TL;DR: Direct evidence is provided to support that the PDA surface modification can serve as an effective strategy to form ultrastable coatings on NPs in vivo, which can improve the intracellular delivery capacity and biocompatibility of NPs for biomedical application.

TL;DR: Simultaneous AuNP aggregation within the MRSA biofilm enhanced the photothermal ablation of methicillin-resistant Staphylococcus aureus biofilm under near-infrared (NIR) light irradiation, and the surrounding healthy tissues showed no damage.

TL;DR: The results suggest that controlled aggregation of NPs sensitive to tumor microenvironment can serve as a universal strategy to enhance the retention and cellular uptake of inorganic NPs in tumors, and modifying NPs with a mixed-charge zwitterionic surface can provide an easy way to obtain stealth properties and pH-sensitivity at the same time.

TL;DR: It is demonstrated that film stiffness strongly modulates adhesion, proliferation and differentiation, each of these processes having its own stiffness requirement.