Ke Shang

TL;DR: Investigation of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of COVID-19 and shows the novel coronavirus might mainly act on lymphocytes, especially T lymphocytes.

TL;DR: Patients with COVID-19 have lower level of regulatory T cells, and more obviously damaged in severe cases, compared with non-severe patients, which suggests surveillance of NLR and lymphocyte subsets is helpful in the early screening of critical illness, diagnosis and treatment of CO VID-19.

TL;DR: In this study, most infections among health care workers occurred during the early stage of the COVID-19 outbreak and in low-contagion areas; routine screening may be helpful in identifying asymptomatic carriers.

TL;DR: Interestingly, FTY720 could reduce cognitive decline and ameliorate the disruption of WM integrity, a potential therapeutic drug targeting brain inflammation by skewing microglia toward M2 polarization after chronic cerebral hypoperfusion.

TL;DR: TLR4-dependent autophagy regulates microglial polarization and induces ischemic white matter damage via STAT1/6 pathway, and TLR4 deficiency could mimic the phenomenon in microglia functional transformation, and exhibit a protective activity in chronic cerebral hypoperfusion.